MIR5090

Summary

MIR5090 (microRNA 5090, HGNC:43547) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847073 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43547
Approved symbol	MIR5090
Name	microRNA 5090
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5090
Ensembl gene	ENSG00000284176
Ensembl biotype	miRNA
Entrez	100847073
RNAcentral	URS0000759904 — ncRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582533

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582533 — 1 exons

Exon	Start	End
ENSE00002696196	102465742	102465826

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 66.65.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial artery	UBERON:0007610	66.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.20	gold quality
blood	UBERON:0000178	66.18	gold quality
transverse colon	UBERON:0001157	65.07	gold quality
ascending aorta	UBERON:0001496	63.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.13	gold quality
anterior cingulate cortex	UBERON:0009835	62.49	gold quality
substantia nigra	UBERON:0002038	62.26	gold quality
esophagus mucosa	UBERON:0002469	60.95	gold quality
right atrium auricular region	UBERON:0006631	60.64	gold quality
skin of abdomen	UBERON:0001416	60.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.98	gold quality
thyroid gland	UBERON:0002046	59.87	gold quality
left lobe of thyroid gland	UBERON:0001120	59.74	gold quality
skin of leg	UBERON:0001511	59.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.46	gold quality
tibial nerve	UBERON:0001323	57.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.90	gold quality
upper lobe of left lung	UBERON:0008952	55.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	54.15	gold quality
nucleus accumbens	UBERON:0001882	53.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.87	gold quality
prostate gland	UBERON:0002367	45.87	gold quality
left testis	UBERON:0004533	29.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.