MIR5091

Summary

MIR5091 (microRNA 5091, HGNC:43478) is a microRNA gene on chromosome 4p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847023 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43478
Approved symbol	MIR5091
Name	microRNA 5091
Location	4p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5091
Ensembl gene	ENSG00000266240
Ensembl biotype	miRNA
Entrez	100847023
RNAcentral	URS000075ABF1 — miRNA, 93 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578707

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578707 — 1 exons

Exon	Start	End
ENSE00002712446	13627865	13627957

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 93.00.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.00	gold quality
calcaneal tendon	UBERON:0003701	83.50	gold quality
bone marrow	UBERON:0002371	83.42	gold quality
blood	UBERON:0000178	79.36	gold quality
vermiform appendix	UBERON:0001154	76.77	gold quality
right uterine tube	UBERON:0001302	75.81	gold quality
right coronary artery	UBERON:0001625	74.72	gold quality
muscle of leg	UBERON:0001383	74.45	gold quality
monocyte	CL:0000576	74.06	gold quality
placenta	UBERON:0001987	73.87	gold quality
adrenal tissue	UBERON:0018303	73.62	gold quality
gastrocnemius	UBERON:0001388	73.33	gold quality
stomach	UBERON:0000945	72.22	gold quality
apex of heart	UBERON:0002098	72.22	gold quality
body of stomach	UBERON:0001161	71.13	gold quality
liver	UBERON:0002107	70.61	gold quality
heart	UBERON:0000948	70.54	gold quality
heart left ventricle	UBERON:0002084	70.54	gold quality
myometrium	UBERON:0001296	70.53	gold quality
lymph node	UBERON:0000029	70.41	gold quality
right lobe of liver	UBERON:0001114	69.86	gold quality
body of pancreas	UBERON:0001150	69.77	gold quality
kidney	UBERON:0002113	69.77	gold quality
adult mammalian kidney	UBERON:0000082	69.48	gold quality
right ovary	UBERON:0002118	69.44	gold quality
left coronary artery	UBERON:0001626	69.31	gold quality
ectocervix	UBERON:0012249	69.29	gold quality
right atrium auricular region	UBERON:0006631	69.26	gold quality
tibial artery	UBERON:0007610	69.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.