MIR5092

Summary

MIR5092 (microRNA 5092, HGNC:43467) is a microRNA gene on chromosome 3q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847039 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43467
Approved symbol	MIR5092
Name	microRNA 5092
Location	3q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5092
Ensembl gene	ENSG00000264986
Ensembl biotype	miRNA
Entrez	100847039
RNAcentral	URS000075BA49 — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583139

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583139 — 1 exons

Exon	Start	End
ENSE00002702494	125151465	125151552

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 85.97.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.97	gold quality
lymph node	UBERON:0000029	77.75	gold quality
monocyte	CL:0000576	77.66	gold quality
blood	UBERON:0000178	77.00	gold quality
placenta	UBERON:0001987	75.60	gold quality
right coronary artery	UBERON:0001625	73.63	gold quality
endometrium	UBERON:0001295	72.74	gold quality
right adrenal gland	UBERON:0001233	71.79	gold quality
left coronary artery	UBERON:0001626	71.34	gold quality
putamen	UBERON:0001874	70.60	gold quality
islet of Langerhans	UBERON:0000006	70.47	gold quality
amygdala	UBERON:0001876	70.21	gold quality
popliteal artery	UBERON:0002250	70.15	gold quality
tibial artery	UBERON:0007610	70.05	gold quality
stomach	UBERON:0000945	69.95	gold quality
ascending aorta	UBERON:0001496	69.86	gold quality
thoracic aorta	UBERON:0001515	69.67	gold quality
smooth muscle tissue	UBERON:0001135	68.38	gold quality
descending thoracic aorta	UBERON:0002345	68.03	gold quality
body of pancreas	UBERON:0001150	67.53	gold quality
anterior cingulate cortex	UBERON:0009835	66.72	gold quality
gastrocnemius	UBERON:0001388	66.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.34	gold quality
left adrenal gland	UBERON:0001234	66.29	gold quality
left adrenal gland cortex	UBERON:0035825	65.67	gold quality
heart left ventricle	UBERON:0002084	65.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.41	gold quality
transverse colon	UBERON:0001157	65.22	gold quality
body of stomach	UBERON:0001161	65.17	gold quality
intestine	UBERON:0000160	65.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.