MIR5093

Summary

MIR5093 (microRNA 5093, HGNC:43474) is a microRNA gene on chromosome 16q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847022 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43474
Approved symbol	MIR5093
Name	microRNA 5093
Location	16q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5093
Ensembl gene	ENSG00000266307
Ensembl biotype	miRNA
Entrez	100847022
RNAcentral	URS000075BEEC — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583199

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583199 — 1 exons

Exon	Start	End
ENSE00002715093	85306226	85306325

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 83.13.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	83.13	gold quality
bone marrow	UBERON:0002371	77.49	gold quality
monocyte	CL:0000576	77.13	gold quality
muscle of leg	UBERON:0001383	75.17	gold quality
right ovary	UBERON:0002118	74.94	gold quality
gastrocnemius	UBERON:0001388	74.79	gold quality
tibial nerve	UBERON:0001323	74.35	gold quality
blood	UBERON:0000178	73.64	gold quality
right adrenal gland cortex	UBERON:0035827	73.31	gold quality
left adrenal gland cortex	UBERON:0035825	72.53	gold quality
anterior cingulate cortex	UBERON:0009835	72.30	gold quality
left adrenal gland	UBERON:0001234	71.80	gold quality
right adrenal gland	UBERON:0001233	71.75	gold quality
stomach	UBERON:0000945	71.36	gold quality
kidney	UBERON:0002113	71.33	gold quality
right atrium auricular region	UBERON:0006631	70.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.04	gold quality
heart left ventricle	UBERON:0002084	69.73	gold quality
liver	UBERON:0002107	69.23	gold quality
thoracic aorta	UBERON:0001515	69.19	gold quality
urinary bladder	UBERON:0001255	69.12	gold quality
thoracic mammary gland	UBERON:0005200	69.07	gold quality
minor salivary gland	UBERON:0001830	69.05	gold quality
ascending aorta	UBERON:0001496	68.99	gold quality
myometrium	UBERON:0001296	68.98	gold quality
endometrium	UBERON:0001295	68.64	gold quality
body of stomach	UBERON:0001161	68.55	gold quality
omental fat pad	UBERON:0010414	68.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.43	gold quality
pituitary gland	UBERON:0000007	68.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.