MIR5094

Summary

MIR5094 (microRNA 5094, HGNC:43519) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847059 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43519
Approved symbol	MIR5094
Name	microRNA 5094
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5094
Ensembl gene	ENSG00000264966
Ensembl biotype	miRNA
Entrez	100847059
RNAcentral	URS000075C8B4 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578766

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578766 — 1 exons

Exon	Start	End
ENSE00002701933	89850637	89850721

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 87.97.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	87.97	gold quality
skeletal muscle tissue	UBERON:0001134	84.97	gold quality
blood	UBERON:0000178	77.99	gold quality
bone marrow	UBERON:0002371	77.90	gold quality
calcaneal tendon	UBERON:0003701	77.49	gold quality
Ammon’s horn	UBERON:0001954	77.45	gold quality
monocyte	CL:0000576	77.10	gold quality
rectum	UBERON:0001052	76.39	gold quality
placenta	UBERON:0001987	76.37	gold quality
muscle of leg	UBERON:0001383	76.09	gold quality
kidney	UBERON:0002113	75.28	gold quality
endometrium	UBERON:0001295	74.95	gold quality
gastrocnemius	UBERON:0001388	74.10	gold quality
lymph node	UBERON:0000029	73.82	gold quality
islet of Langerhans	UBERON:0000006	71.64	gold quality
liver	UBERON:0002107	71.46	gold quality
anterior cingulate cortex	UBERON:0009835	70.64	gold quality
myometrium	UBERON:0001296	69.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.27	gold quality
stomach	UBERON:0000945	69.00	gold quality
nucleus accumbens	UBERON:0001882	69.00	gold quality
body of pancreas	UBERON:0001150	68.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.78	gold quality
right lobe of liver	UBERON:0001114	68.74	gold quality
granulocyte	CL:0000094	68.61	gold quality
body of stomach	UBERON:0001161	68.39	gold quality
tibial artery	UBERON:0007610	68.18	gold quality
heart left ventricle	UBERON:0002084	68.06	gold quality
heart	UBERON:0000948	67.98	gold quality
right atrium auricular region	UBERON:0006631	67.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.