MIR510

Summary

MIR510 (microRNA 510, HGNC:32147) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574515 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32147
Approved symbol	MIR510
Name	microRNA 510
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-510
Ensembl gene	ENSG00000207641
Ensembl biotype	miRNA
OMIM	300866
Entrez	574515
RNAcentral	URS000075EFA3 — miRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384909

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384909 — 1 exons

Exon	Start	End
ENSE00001499916	147272335	147272408

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 72.14.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	72.14	gold quality
monocyte	CL:0000576	70.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.99	gold quality
corpus callosum	UBERON:0002336	68.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.87	gold quality
right lobe of liver	UBERON:0001114	67.71	gold quality
tibial artery	UBERON:0007610	66.77	gold quality
amygdala	UBERON:0001876	66.56	gold quality
right adrenal gland	UBERON:0001233	66.45	gold quality
putamen	UBERON:0001874	66.21	gold quality
colon	UBERON:0001155	65.68	gold quality
transverse colon	UBERON:0001157	65.42	gold quality
substantia nigra	UBERON:0002038	65.34	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.28	gold quality
hypothalamus	UBERON:0001898	65.22	gold quality
nucleus accumbens	UBERON:0001882	64.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.97	gold quality
tibial nerve	UBERON:0001323	62.63	gold quality
right frontal lobe	UBERON:0002810	62.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.02	gold quality
Ammon’s horn	UBERON:0001954	61.61	gold quality
thyroid gland	UBERON:0002046	61.19	gold quality
skin of abdomen	UBERON:0001416	61.14	gold quality
left ovary	UBERON:0002119	60.77	gold quality
anterior cingulate cortex	UBERON:0009835	60.69	gold quality
spleen	UBERON:0002106	58.29	gold quality
caudate nucleus	UBERON:0001873	57.15	gold quality
left testis	UBERON:0004533	41.49	gold quality
testis	UBERON:0000473	41.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• The binding site for miR-510 is solely located in the 3’ UTR of the HTR3E gene. No predicted binding site for miR-510 exists in the 3’ UTR of HTR3A. (PMID:18614545)
• Data show significantly increased expression of miRNA-510 and decreased expression of both miRNA-342 and miRNA-191 in Tregs of diabetic patients. (PMID:19954774)
• MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer. (PMID:23971998)
• Our results revealed that miR-510 was upregulated in blood samples from hypertension patients, compared with controls. Methylation analyses corroborated the miR-510 upregulation in patient samples. (PMID:27881848)
• These results indicated that LINC00702 modulated the expression of PTEN gene by acting as a ceRNA for miR-510 in non-small cell lung cancer. (PMID:30840927)
• Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis. (PMID:34168116)
• Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis. (PMID:36899270)
• MicroRNA-510 mediated negative regulation of Caveolin-1 in fibroblasts promotes aggressive tumor growth. (PMID:37822942)
• Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis. (PMID:37851987)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.