MIR5100

Summary

MIR5100 (microRNA 5100, HGNC:43540) is a microRNA gene on chromosome 10q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847014 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43540
Approved symbol	MIR5100
Name	microRNA 5100
Location	10q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5100
Ensembl gene	ENSG00000263795
Ensembl biotype	miRNA
Entrez	100847014
RNAcentral	URS000075DAD1 — miRNA, 119 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579544

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579544 — 1 exons

Exon	Start	End
ENSE00002690015	42997563	42997681

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 76.07.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.07	gold quality
skin of leg	UBERON:0001511	71.59	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.41	gold quality
transverse colon	UBERON:0001157	65.34	gold quality
esophagus mucosa	UBERON:0002469	64.44	gold quality
skin of abdomen	UBERON:0001416	62.97	gold quality
stomach	UBERON:0000945	56.30	gold quality
right frontal lobe	UBERON:0002810	52.74	gold quality
left testis	UBERON:0004533	42.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. (PMID:25754817)
• Results identify an anti-metastatic miRNA, miR-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL. (PMID:26892887)
• The expression levels of let-7f-5p, miR-5100 and miR-25-3p were significantly associated with the incidence rate of cALL, and these miRNAs might serve as promising biomarkers for cALL[Precursor Cell Lymphoblastic Leukemia-Lymphoma]. (PMID:28910942)
• Multivariate survival analysis verified that miR-5100 expression level was an independent predictor of both overall survival and progression-free survival for non-small-cell lung cancer patients (PMID:28925485)
• These results suggest that miR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6. (PMID:29144562)
• mir-5100 expression was higher in patients with SLE compared to controls, in patients with SLE compared to patients with rheumatoid arthritis, and in patients with active SLE compared to inactive SLE. (PMID:30304699)
• High miR5100 expression is associated with metastasis of lung cancer. (PMID:30866952)
• MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells. (PMID:32315812)
• MicroRNA expression profiling in acute kidney injury. (PMID:34871811)
• Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis. (PMID:35563178)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.