MIR511

Summary

MIR511 (microRNA 511, HGNC:32077) is a microRNA gene on chromosome 10p12.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574445 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32077
Approved symbol	MIR511
Name	microRNA 511
Location	10p12.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-511-1, hsa-mir-511-2
Ensembl gene	ENSG00000207938
Ensembl biotype	miRNA
Entrez	574445
RNAcentral	URS00006BADF6 — miRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385203

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385203 — 1 exons

Exon	Start	End
ENSE00001807052	17845107	17845193

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 77.93.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.93	gold quality
blood	UBERON:0000178	77.78	gold quality
adrenal tissue	UBERON:0018303	77.00	gold quality
kidney	UBERON:0002113	74.73	gold quality
left adrenal gland cortex	UBERON:0035825	74.38	gold quality
liver	UBERON:0002107	74.31	gold quality
gastrocnemius	UBERON:0001388	73.79	gold quality
heart left ventricle	UBERON:0002084	73.57	gold quality
caudate nucleus	UBERON:0001873	72.95	gold quality
left adrenal gland	UBERON:0001234	72.03	gold quality
heart	UBERON:0000948	71.79	gold quality
body of stomach	UBERON:0001161	71.71	gold quality
calcaneal tendon	UBERON:0003701	71.39	gold quality
right adrenal gland cortex	UBERON:0035827	71.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.77	gold quality
stomach	UBERON:0000945	69.66	gold quality
intestine	UBERON:0000160	68.54	gold quality
right atrium auricular region	UBERON:0006631	67.93	gold quality
urinary bladder	UBERON:0001255	67.77	gold quality
left coronary artery	UBERON:0001626	67.59	gold quality
body of pancreas	UBERON:0001150	67.34	gold quality
right lobe of liver	UBERON:0001114	66.73	gold quality
colon	UBERON:0001155	66.68	gold quality
substantia nigra	UBERON:0002038	66.58	gold quality
transverse colon	UBERON:0001157	66.29	gold quality
skin of abdomen	UBERON:0001416	65.68	gold quality
right frontal lobe	UBERON:0002810	65.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.57	gold quality
minor salivary gland	UBERON:0001830	65.35	gold quality
ascending aorta	UBERON:0001496	65.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 26)

• miR-511-3p, a miRNA encoded by the miR-511 gene and located in the mannose receptor gene (MRC1), downregulates ROCK2 and modulates the genetic programs of tumor-associated macrophages in mouse models of cancer. (PMID:22832163)
• results illustrate that miR-511 and miR-1297 act as tumor suppressor genes, which could suppress A549 cell proliferation in vitro and in vivo by suppressing TRIB2 and further increasing C/EBPalpha expression (PMID:23071539)
• miR-511 regulates the growth of radioresistant lung cancer cells by increasing BAX expression through TRIB2. (PMID:24402374)
• Notably, the brain-expressed, species-conserved miR-511 binds to MECP2 3’UTR only in rs2734647 T carriers, thereby suppressing gene expression. (PMID:24648499)
• The various levels of specific miRNAs, particularly miR-593 and miR-511 whose direct target is the PROP1 gene, may serve as a non-invasive diagnostic biomarkers for children with CPHD. (PMID:25434367)
• our findings provide new insights into tumor suppression by miR-511 by negatively regulating the PIK3R3/AKT/mTOR signaling pathway (PMID:25608840)
• this study shows that miR-511-3p contributes to intestinal inflammation (PMID:26530135)
• Data identified miR-511 as is strongly repressed by MLL-AF9 in monoblastic acute myeloid leukemia. (PMID:26762252)
• findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation. (PMID:27334923)
• Study indicates that downregulation of miR-511 accounts for the aberrant overexpression of TRIM24 in gastric tumorigenesis. MiR-511-mediated suppression of TRIM24 inhibits cell proliferation through PI3K/AKT and Wnt/beta-catenin pathways. (PMID:28114950)
• promotes the proliferation of hepatoma cells by targeting the 3’UTR of B cell translocation gene 1 (BTG1) mRNA (PMID:28603285)
• MiR-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3. (PMID:28624527)
• Data show that TLR4 was the miR-511-5p direct target responsible for glucocorticoids- and TGF-beta-mediated inhibition of pro-inflammatory cytokines production observed in endotoxin tolerant monocytes. (PMID:28776644)
• circZFR promotes hepatocellular carcinoma progression by directly down-regulating miR-511 to activate AKT1 signaling, suggesting that circZFR is a potential target in HCC treatment. (PMID:31147216)
• MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116. (PMID:31364112)
• miR-511 is lowly expressed in osteosarcoma cells while MAPK1 is highly expressed. Overexpression of miR-511 by miR-511 mimic transfection may result in low expression of MAPK1, and inhibits the development of osteosarcoma MG63 cell, including proliferation and invasion. miR-511 mimic transfection reduces metastatic osteosarcoma tumor burden in nude mice by targeting MAPK1. (PMID:31524148)
• circRNA-associated ceRNA network construction reveals the circRNAs involved in the progression and prognosis of breast cancer. (PMID:31617204)
• miR-511 inhibits proliferation and metastasis of breast cancer cells by targeting FGF4. (PMID:32023352)
• CircRNA_001010 adsorbs miR-5112 in a sponge form to promote proliferation and metastasis of non-small cell lung cancer (NSCLC). (PMID:32373963)
• LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis. (PMID:32524841)
• miR-511-5p Suppresses Cell Migration, Invasion and Epithelial-Mesenchymal Transition Through Targeting PAK2 in Gastric Cancer. (PMID:34542739)
• Exosomal lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)contributes to the progression of allergic rhinitis via modulating microRNA-511/Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) axis. (PMID:34672863)
• lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis. (PMID:34989314)
• Bioinformatics Analysis Reveals the Related Role of miR-511-5p in the Progression of Breast Cancer. (PMID:35186236)
• MicroRNA-511-3p regulates Abeta1-40 induced decreased cell viability and serves as a candidate biomarker in Alzheimer’s disease. (PMID:37121335)
• Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. (PMID:39107843)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.