MIR512-2

Summary

MIR512-2 (microRNA 512-2, HGNC:32091) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574459 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32091
Approved symbol	MIR512-2
Name	microRNA 512-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-512-2
Ensembl gene	ENSG00000207644
Ensembl biotype	miRNA
OMIM	620572
Entrez	574459
RNAcentral	URS000075A8E9 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384912

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384912 — 1 exons

Exon	Start	End
ENSE00001809002	53669157	53669254

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 83.61.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.61	gold quality
monocyte	CL:0000576	79.64	gold quality
gastrocnemius	UBERON:0001388	76.10	gold quality
heart left ventricle	UBERON:0002084	74.75	gold quality
placenta	UBERON:0001987	73.44	gold quality
left ovary	UBERON:0002119	72.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.89	gold quality
skin of abdomen	UBERON:0001416	72.38	gold quality
right atrium auricular region	UBERON:0006631	72.07	gold quality
left adrenal gland cortex	UBERON:0035825	71.98	gold quality
fundus of stomach	UBERON:0001160	71.82	gold quality
left adrenal gland	UBERON:0001234	71.52	gold quality
thoracic aorta	UBERON:0001515	69.66	gold quality
ascending aorta	UBERON:0001496	69.38	gold quality
body of stomach	UBERON:0001161	69.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.73	gold quality
upper lobe of left lung	UBERON:0008952	68.20	gold quality
right lobe of liver	UBERON:0001114	68.19	gold quality
blood	UBERON:0000178	68.08	gold quality
tibial artery	UBERON:0007610	67.72	gold quality
esophagus mucosa	UBERON:0002469	67.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.38	gold quality
omental fat pad	UBERON:0010414	66.94	gold quality
skin of leg	UBERON:0001511	66.74	gold quality
transverse colon	UBERON:0001157	66.70	gold quality
body of uterus	UBERON:0009853	66.31	gold quality
urinary bladder	UBERON:0001255	65.45	gold quality
vagina	UBERON:0000996	65.32	gold quality
spleen	UBERON:0002106	64.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. (microRNA-512-5p) (PMID:19503096)
• Disclose a novel regulatory mechanism inHepG2 cells where down-regulation of c-FLIP by miR-512-3p contributed to taxol-induced apoptosis. (PMID:20372864)
• LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis. (PMID:32858372)
• Hsa_circ_0005576 promotes osimertinib resistance through the miR-512-5p/IGF1R axis in lung adenocarcinoma cells. (PMID:34706132)
• miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma. (PMID:36078082)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.