MIR513A1

Summary

MIR513A1 (microRNA 513a-1, HGNC:32141) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574509 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32141
Approved symbol	MIR513A1
Name	microRNA 513a-1
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-513-1, hsa-mir-513a-1
Ensembl gene	ENSG00000207873
Ensembl biotype	miRNA
Entrez	574509
RNAcentral	URS000075E43A — miRNA, 129 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385138 — 1 exons

Exon	Start	End
ENSE00001500144	147213463	147213591

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 89.64.

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	89.64	gold quality
adult mammalian kidney	UBERON:0000082	76.63	gold quality
cortex of kidney	UBERON:0001225	70.33	gold quality
right lobe of liver	UBERON:0001114	70.19	gold quality
liver	UBERON:0002107	70.00	gold quality
stomach	UBERON:0000945	69.95	gold quality
body of pancreas	UBERON:0001150	69.13	gold quality
skin of leg	UBERON:0001511	68.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.36	gold quality
ascending aorta	UBERON:0001496	68.20	gold quality
gastrocnemius	UBERON:0001388	67.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.40	gold quality
omental fat pad	UBERON:0010414	66.66	gold quality
left ovary	UBERON:0002119	66.44	gold quality
colon	UBERON:0001155	66.27	gold quality
esophagus mucosa	UBERON:0002469	66.20	gold quality
tibial artery	UBERON:0007610	65.91	gold quality
transverse colon	UBERON:0001157	65.33	gold quality
intestine	UBERON:0000160	65.19	gold quality
tibial nerve	UBERON:0001323	64.90	gold quality
spleen	UBERON:0002106	64.53	gold quality
caudate nucleus	UBERON:0001873	64.00	gold quality
corpus callosum	UBERON:0002336	63.97	gold quality
body of uterus	UBERON:0009853	63.39	gold quality
ectocervix	UBERON:0012249	63.38	gold quality
nucleus accumbens	UBERON:0001882	63.23	gold quality
gall bladder	UBERON:0002110	63.14	gold quality
metanephros cortex	UBERON:0010533	62.86	gold quality
Ammon’s horn	UBERON:0001954	62.68	gold quality
left adrenal gland	UBERON:0001234	62.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• miR-513a-3p is involved in the control of the LHCGR expression by an inversely regulated mechanism at the post-transcriptional level. (PMID:24747085)
• Low expression of miR-513b is associated with lymph node metastases in gastric cancer. (PMID:25095979)
• MiR-513a-5p promotes dichlorvos induced apoptosis by targeting Bcl-2. (PMID:30372899)
• Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma. (PMID:32342645)
• LncRNA PCAT6 aggravates the progression of bladder cancer cells by targeting miR-513a-5p. (PMID:33090394)
• [Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway]. (PMID:33113626)
• MiR-513a-3p inhibits EMT mediated by HOXB7 and promotes sensitivity to cisplatin in ovarian cancer cells. (PMID:33155195)
• lncRNA MIR4435-2HG promoted clear cell renal cell carcinoma malignant progression via miR-513a-5p/KLF6 axis. (PMID:33460239)
• Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis. (PMID:33979737)
• Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin. (PMID:34903127)
• MiR-513a-3p promotes radiation-induced apoptosis of human lung cells by inhibiting glutathione S-transferase P1. (PMID:35459441)
• CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells. (PMID:36111570)
• Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p. (PMID:36255069)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.