MIR513A2

Summary

MIR513A2 (microRNA 513a-2, HGNC:32142) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574510 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32142
Approved symbol	MIR513A2
Name	microRNA 513a-2
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-513-2
Ensembl gene	ENSG00000207984
Ensembl biotype	miRNA
Entrez	574510
RNAcentral	URS000075DF42 — miRNA, 127 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385249

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385249 — 1 exons

Exon	Start	End
ENSE00001500255	147225826	147225952

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 84.83.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.83	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.90	gold quality
liver	UBERON:0002107	69.65	gold quality
adult mammalian kidney	UBERON:0000082	68.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.02	gold quality
right lobe of liver	UBERON:0001114	67.92	gold quality
body of pancreas	UBERON:0001150	67.48	gold quality
caudate nucleus	UBERON:0001873	67.06	gold quality
tibial nerve	UBERON:0001323	66.45	gold quality
colon	UBERON:0001155	65.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.58	gold quality
transverse colon	UBERON:0001157	65.35	gold quality
ascending aorta	UBERON:0001496	63.90	gold quality
metanephros cortex	UBERON:0010533	63.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.58	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.03	gold quality
brain	UBERON:0000955	60.61	gold quality
Ammon’s horn	UBERON:0001954	58.24	gold quality
putamen	UBERON:0001874	58.05	gold quality
corpus callosum	UBERON:0002336	55.39	gold quality
left testis	UBERON:0004533	49.74	gold quality
testis	UBERON:0000473	49.42	gold quality
right testis	UBERON:0004534	48.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• miR-513a-3p is involved in the control of the LHCGR expression by an inversely regulated mechanism at the post-transcriptional level. (PMID:24747085)
• Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma. (PMID:32342645)
• [Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway]. (PMID:33113626)
• Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis. (PMID:33979737)
• CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells. (PMID:36111570)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir511	ENSMUSG00000077897

Paralogs (9): MIR506 (ENSG00000207731), MIR514A2 (ENSG00000207866), MIR514A3 (ENSG00000207867), MIR514A1 (ENSG00000207868), MIR513B (ENSG00000207871), MIR507 (ENSG00000207969), MIR509-1 (ENSG00000208000), MIR509-3 (ENSG00000212014), MIR514B (ENSG00000252583)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.