MIR513B

Summary

MIR513B (microRNA 513b, HGNC:33935) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313822 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33935
Approved symbol	MIR513B
Name	microRNA 513b
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-513b
Ensembl gene	ENSG00000207871
Ensembl biotype	miRNA
Entrez	100313822
RNAcentral	URS000075C5E7 — miRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385136

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385136 — 1 exons

Exon	Start	End
ENSE00001808257	147199044	147199127

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 79.30.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	79.30	gold quality
liver	UBERON:0002107	73.74	gold quality
colon	UBERON:0001155	70.45	gold quality
right lobe of liver	UBERON:0001114	69.86	gold quality
right atrium auricular region	UBERON:0006631	69.13	gold quality
left ovary	UBERON:0002119	64.45	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.45	gold quality
transverse colon	UBERON:0001157	63.77	gold quality
testis	UBERON:0000473	46.27	gold quality
left testis	UBERON:0004533	45.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• In conclusion, the authors suggest that NF-kappaB is capable of enhancing the expression of PCT by either directly activating the transcription of the PCT gene or indirectly modulating the expression of its regulatory component, miR-513b. (PMID:29891911)
• miR-513b was downregulated in non-small cell lung carcinoma cells and could regulate the proliferation, invasion, migration, and apoptosis of NSCLC cells via HMGB3 and mTOR signaling pathway. (PMID:30623409)
• LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR513b5p and regulating the PTEN/AKT/mTOR signaling pathway. (PMID:33179755)
• Silencing of FTX suppresses pancreatic cancer cell proliferation and invasion by upregulating miR-513b-5p. (PMID:33736615)
• MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3. (PMID:34120890)
• MicroRNA-513b-5p targets COL1A1 and COL1A2 associated with the formation and rupture of intracranial aneurysm. (PMID:34290266)
• N(6)-Methyladenosine-regulated LINC00675 suppress the proliferation, migration and invasion of breast cancer cells via inhibiting miR-513b-5p. (PMID:34738869)
• Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis. (PMID:35818196)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir511	ENSMUSG00000077897

Paralogs (9): MIR506 (ENSG00000207731), MIR514A2 (ENSG00000207866), MIR514A3 (ENSG00000207867), MIR514A1 (ENSG00000207868), MIR507 (ENSG00000207969), MIR513A2 (ENSG00000207984), MIR509-1 (ENSG00000208000), MIR509-3 (ENSG00000212014), MIR514B (ENSG00000252583)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.