MIR513C

Summary

MIR513C (microRNA 513c, HGNC:33934) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302114 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33934
Approved symbol	MIR513C
Name	microRNA 513c
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-513c
Ensembl gene	ENSG00000216171
Ensembl biotype	miRNA
Entrez	100302114
RNAcentral	URS000075A3A1 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401352

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401352 — 1 exons

Exon	Start	End
ENSE00001808341	147189704	147189787

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 79.37.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	79.37	gold quality
blood	UBERON:0000178	75.47	gold quality
right lobe of liver	UBERON:0001114	68.62	gold quality
small intestine	UBERON:0002108	66.87	gold quality
transverse colon	UBERON:0001157	64.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.59	gold quality
left ovary	UBERON:0002119	63.27	gold quality
vagina	UBERON:0000996	63.16	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality
left testis	UBERON:0004533	42.36	gold quality
testis	UBERON:0000473	41.92	gold quality
right testis	UBERON:0004534	39.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• miR513c functions as a tumor suppressor miRNA, mediated predominantly through the direct suppression of the expression of LRP6. (PMID:26063413)
• Overexpression of miR-513c suppresses neuroblastoma cells’ migration, invasion, and proliferation. We demonstrate the glutaminase (GLS) is a direct target of miR-513c in human neuroblastoma cells. (PMID:28800318)
• Low expression of MIR513C due to LncRNA FLVCR1-AS1 sponge is associated with migration, and invasion in hepatocellular carcinoma. (PMID:29574975)
• Results show that miR-513c directly targets TCF7. Its expression is regulated by LOC728196 which acts as the sponge for miR-513c to upregulate TCF7 expression in glioma cells. (PMID:30179681)
• MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6. (PMID:34930169)
• hsa-miR-424-5p and hsa-miR-513c-3p dysregulation mediated by IFN-gamma is associated with salivary gland dysfunction in Sjogren’s syndrome patients. (PMID:37229808)
• lncRNA SEMA3B-AS1 Inhibits miR-513c-5p to Regulate the Progression of Triple-negative Breast Cancer. (PMID:38030196)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.