MIR514A1

Summary

MIR514A1 (microRNA 514a-1, HGNC:32148) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574516 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32148
Approved symbol	MIR514A1
Name	microRNA 514a-1
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-514-1
Ensembl gene	ENSG00000207868
Ensembl biotype	miRNA
Entrez	574516
RNAcentral	URS000075E537 — miRNA, 98 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385133

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385133 — 1 exons

Exon	Start	End
ENSE00001500139	147279247	147279344

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 77.79.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.79	gold quality
adult mammalian kidney	UBERON:0000082	74.83	gold quality
substantia nigra	UBERON:0002038	72.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.37	gold quality
body of pancreas	UBERON:0001150	71.63	gold quality
adrenal tissue	UBERON:0018303	71.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.43	gold quality
right frontal lobe	UBERON:0002810	68.97	gold quality
esophagus mucosa	UBERON:0002469	67.79	gold quality
transverse colon	UBERON:0001157	67.78	gold quality
tibial nerve	UBERON:0001323	67.49	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.23	gold quality
left ovary	UBERON:0002119	66.14	gold quality
skin of abdomen	UBERON:0001416	65.73	gold quality
skin of leg	UBERON:0001511	64.91	gold quality
hypothalamus	UBERON:0001898	62.63	gold quality
pituitary gland	UBERON:0000007	60.00	gold quality
left testis	UBERON:0004533	47.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-514a has the ability to bind to NF1 and inhibit its translation, and miR-514a expression is involved in modulating cell proliferation rates along with BRAFi (PLX4032) sensitivity in melanoma. (PMID:25980496)
• Loss of miR-514a-3p expression in testicular germ cell tumor increases PEG3 expression that recruits TRAF2 and activates the NF-kappa B pathway, which protects germ cells from apoptosis. (PMID:28471449)
• LncRNA SNHG7 promotes the proliferation of nasopharyngeal carcinoma by miR-514a-5p/ELAVL1 axis. (PMID:32370736)
• Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis. (PMID:33195693)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir509	ENSMUSG00000106233

Paralogs (9): MIR506 (ENSG00000207731), MIR514A2 (ENSG00000207866), MIR514A3 (ENSG00000207867), MIR513B (ENSG00000207871), MIR507 (ENSG00000207969), MIR513A2 (ENSG00000207984), MIR509-1 (ENSG00000208000), MIR509-3 (ENSG00000212014), MIR514B (ENSG00000252583)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.