MIR514B

Summary

MIR514B (microRNA 514b, HGNC:38292) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422847 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38292
Approved symbol	MIR514B
Name	microRNA 514b
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-514b
Ensembl gene	ENSG00000252583
Ensembl biotype	miRNA
Entrez	100422847
RNAcentral	URS000075B7D5 — miRNA, 80 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516774

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516774 — 1 exons

Exon	Start	End
ENSE00002089051	147250151	147250230

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 77.75.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	77.75	gold quality
endometrium	UBERON:0001295	77.65	gold quality
gall bladder	UBERON:0002110	72.92	gold quality
kidney	UBERON:0002113	72.53	gold quality
adult mammalian kidney	UBERON:0000082	72.41	gold quality
liver	UBERON:0002107	72.33	gold quality
right lobe of liver	UBERON:0001114	71.29	gold quality
metanephros cortex	UBERON:0010533	70.35	gold quality
putamen	UBERON:0001874	69.14	gold quality
colon	UBERON:0001155	69.02	gold quality
transverse colon	UBERON:0001157	68.96	gold quality
intestine	UBERON:0000160	68.18	gold quality
lung	UBERON:0002048	67.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.92	gold quality
amygdala	UBERON:0001876	65.18	gold quality
nucleus accumbens	UBERON:0001882	64.91	gold quality
caudate nucleus	UBERON:0001873	64.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.94	gold quality
hypothalamus	UBERON:0001898	63.75	gold quality
brain	UBERON:0000955	63.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.64	gold quality
cerebral cortex	UBERON:0000956	62.89	gold quality
substantia nigra	UBERON:0002038	62.52	gold quality
anterior cingulate cortex	UBERON:0009835	62.25	gold quality
Ammon’s horn	UBERON:0001954	62.18	gold quality
right frontal lobe	UBERON:0002810	61.26	gold quality
vagina	UBERON:0000996	60.17	gold quality
cerebellar hemisphere	UBERON:0002245	58.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• though miR-514b-3p and miR-514b-5p were transcribed from the same RNA hairpin, each microRNA has distinct effect on colorectal cancer metastasis. (PMID:29880874)
• Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis. (PMID:34281459)
• LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression. (PMID:35947460)
• Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta. (PMID:36180981)
• Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC. (PMID:38217675)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir509	ENSMUSG00000106233

Paralogs (9): MIR506 (ENSG00000207731), MIR514A2 (ENSG00000207866), MIR514A3 (ENSG00000207867), MIR514A1 (ENSG00000207868), MIR513B (ENSG00000207871), MIR507 (ENSG00000207969), MIR513A2 (ENSG00000207984), MIR509-1 (ENSG00000208000), MIR509-3 (ENSG00000212014)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.