MIR515-1

Summary

MIR515-1 (microRNA 515-1, HGNC:32094) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574462 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32094
Approved symbol	MIR515-1
Name	microRNA 515-1
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-515-1
Ensembl gene	ENSG00000207616
Ensembl biotype	miRNA
OMIM	620574
Entrez	574462
RNAcentral	URS00006C1198 — miRNA, 83 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384884 — 1 exons

Exon	Start	End
ENSE00001808932	53679003	53679085

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 72.83.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	72.83	gold quality
monocyte	CL:0000576	72.43	gold quality
skin of leg	UBERON:0001511	72.06	gold quality
blood	UBERON:0000178	68.82	gold quality
gastrocnemius	UBERON:0001388	66.67	gold quality
stomach	UBERON:0000945	65.66	gold quality
amygdala	UBERON:0001876	64.34	gold quality
tibial artery	UBERON:0007610	64.26	gold quality
body of stomach	UBERON:0001161	63.61	gold quality
right adrenal gland	UBERON:0001233	60.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.25	gold quality
ascending aorta	UBERON:0001496	58.75	gold quality
esophagus mucosa	UBERON:0002469	58.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.26	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.66	gold quality
myometrium	UBERON:0001296	57.36	gold quality
tibial nerve	UBERON:0001323	56.90	gold quality
skin of abdomen	UBERON:0001416	56.87	gold quality
hypothalamus	UBERON:0001898	56.60	gold quality
right frontal lobe	UBERON:0002810	55.28	gold quality
ectocervix	UBERON:0012249	54.05	gold quality
left lobe of thyroid gland	UBERON:0001120	51.77	gold quality
right testis	UBERON:0004534	42.60	gold quality
left testis	UBERON:0004533	34.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• The direct regulatory role of miR-515-5p on IGF-1R mRNA and protein expression (PMID:23549953)
• Loss of microRNA-515 is associated with breast cancer. (PMID:23928990)
• data demonstrate that miR-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types (PMID:26882547)
• MiR-515-5p in non-small cell lung cancer (NSCLC) cells could inhibit NSCLC survival and metastasis (PMID:29136957)
• circ_0067997 was identified to be an oncogene in GC by regulating miR-515-5p/XIAP axis (PMID:30688097)
• Serum miR-515-3p, a potential new RNA biomarker, is involved in gastric carcinoma. (PMID:31081157)
• LINC00511 promotes proliferation and invasion by sponging miR-515-5p in gastric cancer. (PMID:32042282)
• Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p. (PMID:32141558)
• The effect of LINC00519-miR-450b-5p-miR-515-5p-YAP1 axis in LUSC. (PMID:32297697)
• Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/beta-Catenin Axis. (PMID:32561925)
• miR-515-5p suppresses HCC migration and invasion via targeting IL6/JAK/STAT3 pathway. (PMID:32891315)
• Circular RNA circ_0032821 contributes to oxaliplatin (OXA) resistance of gastric cancer cells by regulating SOX9 via miR-515-5p. (PMID:33123829)
• CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma. (PMID:33536745)
• CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis. (PMID:34469009)
• Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma. (PMID:34781814)
• Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis. (PMID:34982022)
• LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis. (PMID:35034539)
• Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells. (PMID:35143103)
• miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia. (PMID:36155776)
• circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6. (PMID:36892025)
• Endogenous hsa-circ_0007113 binds hsa-miR-515-5p to regulate senescence in human embryonic lung fibroblasts. (PMID:38141006)
• [miR-515-5p targeting Toll-like receptor 4 regulates myeloid differentiation primary response gene 88/nuclear factor-kappa B pathway to inhibit apoptosis and inflammatory response of osteoarthritis chondrocytes]. (PMID:38500425)
• M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. (PMID:38755265)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.