MIR516A1

Summary

MIR516A1 (microRNA 516a-1, HGNC:32130) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574498 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32130
Approved symbol	MIR516A1
Name	microRNA 516a-1
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-516-1, hsa-mir-516a-1
Ensembl gene	ENSG00000207767
Ensembl biotype	miRNA
OMIM	620626
Entrez	574498
RNAcentral	URS00006DFB5F — miRNA, 90 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385033

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385033 — 1 exons

Exon	Start	End
ENSE00001807778	53756741	53756830

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 78.78.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ascending aorta	UBERON:0001496	78.78	gold quality
thoracic aorta	UBERON:0001515	76.30	gold quality
monocyte	CL:0000576	72.14	gold quality
heart left ventricle	UBERON:0002084	71.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.59	gold quality
placenta	UBERON:0001987	69.37	gold quality
left lobe of thyroid gland	UBERON:0001120	68.43	gold quality
right lobe of liver	UBERON:0001114	67.45	gold quality
right atrium auricular region	UBERON:0006631	67.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.92	gold quality
gastrocnemius	UBERON:0001388	66.75	gold quality
tibial artery	UBERON:0007610	65.84	gold quality
skin of abdomen	UBERON:0001416	65.50	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.48	gold quality
left ovary	UBERON:0002119	63.39	gold quality
esophagus mucosa	UBERON:0002469	63.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.62	gold quality
urinary bladder	UBERON:0001255	61.28	gold quality
spleen	UBERON:0002106	61.26	gold quality
omental fat pad	UBERON:0010414	60.28	gold quality
right adrenal gland	UBERON:0001233	59.66	gold quality
transverse colon	UBERON:0001157	58.27	gold quality
tibial nerve	UBERON:0001323	57.19	gold quality
prostate gland	UBERON:0002367	54.28	gold quality
lung	UBERON:0002048	43.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Report increased miR-516a-5p expression in human abdominal aortic aneurysms. (PMID:23746831)
• miRNA-516a-3p, miRNA-629 and miRNA-525-5p are expressed in pediatric SLE patients with active disease (PMID:24687380)
• Expression of maternal miR-487b and paternal miR-516a-5p improves the risk stratification in neuroblastoma. (PMID:24931722)
• circular RNA 100290 has a role in promoting colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling (PMID:30173892)
• Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. (PMID:31822654)
• Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy. (PMID:32116109)
• miR-516a-3P, a potential circulating biomarker in hepatocellular carcinoma, correlated with rs738409 polymorphism in PNPLA3. (PMID:36239555)
• The hsa-miR-516a-5p and hsa-miR-516b-5p microRNAs reduce the migration and invasion on T98G glioblastoma cell line. (PMID:36410106)
• Construction and integrated analysis of the ceRNA network hsa_circ_0000672/miR-516a-5p/TRAF6 and its potential function in atrial fibrillation. (PMID:37169841)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.