MIR516A2

Summary

MIR516A2 (microRNA 516a-2, HGNC:32131) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574499 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32131
Approved symbol	MIR516A2
Name	microRNA 516a-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-516-2, hsa-mir-516a-2
Ensembl gene	ENSG00000207620
Ensembl biotype	miRNA
OMIM	620627
Entrez	574499
RNAcentral	URS000062C88B — miRNA, 90 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384888

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384888 — 1 exons

Exon	Start	End
ENSE00001808626	53761133	53761222

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 76.19.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.19	gold quality
blood	UBERON:0000178	72.05	gold quality
ascending aorta	UBERON:0001496	71.81	gold quality
heart left ventricle	UBERON:0002084	71.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.59	gold quality
placenta	UBERON:0001987	69.37	gold quality
right atrium auricular region	UBERON:0006631	67.13	gold quality
nucleus accumbens	UBERON:0001882	67.02	gold quality
gastrocnemius	UBERON:0001388	66.75	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.82	gold quality
left ovary	UBERON:0002119	64.27	gold quality
vagina	UBERON:0000996	62.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.62	gold quality
transverse colon	UBERON:0001157	60.95	gold quality
esophagus mucosa	UBERON:0002469	60.10	gold quality
right adrenal gland	UBERON:0001233	59.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.15	gold quality
tibial nerve	UBERON:0001323	57.19	gold quality
prostate gland	UBERON:0002367	54.28	gold quality
lung	UBERON:0002048	43.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Report increased miR-516a-5p expression in human abdominal aortic aneurysms. (PMID:23746831)
• miRNA-516a-3p, miRNA-629 and miRNA-525-5p are expressed in pediatric SLE patients with active disease (PMID:24687380)
• Expression of maternal miR-487b and paternal miR-516a-5p improves the risk stratification in neuroblastoma. (PMID:24931722)
• circular RNA 100290 has a role in promoting colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling (PMID:30173892)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.