MIR516B2

Summary

MIR516B2 (microRNA 516b-2, HGNC:32117) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574485 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32117
Approved symbol	MIR516B2
Name	microRNA 516b-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-516-3, hsa-mir-516b-2
Ensembl gene	ENSG00000207925
Ensembl biotype	miRNA
OMIM	620614
Entrez	574485
RNAcentral	URS00006D6272 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385190 — 1 exons

Exon	Start	End
ENSE00001500196	53725442	53725526

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 97.39.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.39	gold quality
placenta	UBERON:0001987	75.05	gold quality
body of stomach	UBERON:0001161	74.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.04	gold quality
right atrium auricular region	UBERON:0006631	69.26	gold quality
esophagus mucosa	UBERON:0002469	63.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.47	gold quality
left uterine tube	UBERON:0001303	60.63	gold quality
left testis	UBERON:0004533	43.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells. (PMID:30119241)
• Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11/miR516b5p axis. (PMID:33174014)
• Late/post-term decidual basalis-derived mesenchymal stem/stromal cells show evidence of advanced ageing and downregulation of microRNA-516b-5p. (PMID:33975264)
• The hsa-miR-516a-5p and hsa-miR-516b-5p microRNAs reduce the migration and invasion on T98G glioblastoma cell line. (PMID:36410106)
• LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer. (PMID:36730555)
• Circ_CHMP5 aggravates oxidized low-density lipoprotein-induced damage to human umbilical vein endothelial cells through miR-516b-5p/TGFbetaR2 axis. (PMID:37212088)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.