MIR517A

Summary

MIR517A (microRNA 517a, HGNC:32111) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574479 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32111
Approved symbol	MIR517A
Name	microRNA 517a
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-517a
Ensembl gene	ENSG00000207734
Ensembl biotype	miRNA
OMIM	620600
Entrez	574479
RNAcentral	URS00006C1AF2 — miRNA, 87 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385001

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385001 — 1 exons

Exon	Start	End
ENSE00001807112	53712268	53712354

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 76.46.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.46	gold quality
omental fat pad	UBERON:0010414	69.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.96	gold quality
prostate gland	UBERON:0002367	62.23	gold quality
spleen	UBERON:0002106	58.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• two stem cell microRNA gene clusters C19MC (miR-512-5p, miR-517a, and miR-519a)and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas (PMID:20209130)
• miR-517a functions as a tumor suppressor through inhibition of cell proliferation and induction of apoptosis in bladder cancer cells (PMID:21479368)
• underexpressed in complete hydatidiform mole (PMID:22672989)
• Down-regulation of both miR-517a and miR-517c contribute to hepatocellular carcinoma cells development through regulating Pyk2. (PMID:23142219)
• This study demonstrated that miR-517a-3p promoted lung cancer cell proliferation and invasion by targeting of FOXJ3 expression (PMID:24846831)
• Expression levels of miR-517a-3p and its target mRNA PRKG1 were inversely correlated in NK cells before and after obstetric delivery. (PMID:25273530)
• MiR-517a overexpression increased expression of the anti-angiogenic protein, sFLT1. (PMID:25799546)
• Increased levels of cell-free miR-517a in maternal plasma samples from placenta previa pregnancies at 32 weeks gestational age may be a predictive marker for the risks of alert bleeding later and massive hemorrhage at delivery. (PMID:26040940)
• MiR-517-5p is highly expressed in placental samples of preeclampsia pregnancies, which could promote proliferative and invasive abilities of cells by inhibiting ERK/MMP-2 pathway. (PMID:30402831)
• Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a. (PMID:33093239)
• LncRNA-SNX17 Promotes HTR-8/SVneo Proliferation and Invasion Through miR-517a/IGF-1 in the Placenta of Diabetic Macrosomia. (PMID:34270000)
• A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity. (PMID:34298423)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.