MIR517B

Summary

MIR517B (microRNA 517b, HGNC:32115) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574483 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32115
Approved symbol	MIR517B
Name	microRNA 517b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-517b
Ensembl gene	ENSG00000207837
Ensembl biotype	miRNA
OMIM	620613
Entrez	574483
RNAcentral	URS000075C4A5 — miRNA, 67 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385102

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385102 — 1 exons

Exon	Start	End
ENSE00001500108	53721076	53721142

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 78.95.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.95	gold quality
placenta	UBERON:0001987	77.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.18	gold quality
right ovary	UBERON:0002118	65.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• underexpressed in complete hydatidiform mole (PMID:22672989)
• MiR-517b overexpression increased expression of the anti-angiogenic protein, sFLT1. (PMID:25799546)
• MiR-517-5p is highly expressed in placental samples of preeclampsia pregnancies, which could promote proliferative and invasive abilities of cells by inhibiting ERK/MMP-2 pathway. (PMID:30402831)
• miR-517b-3p promotes the progression of portal vein tumor thrombus via activating Wnt/beta-catenin signaling pathway in hepatocellular carcinoma. (PMID:35666423)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.