MIR517C

Summary

MIR517C (microRNA 517c, HGNC:32124) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574492 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32124
Approved symbol	MIR517C
Name	microRNA 517c
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-517c
Ensembl gene	ENSG00000207838
Ensembl biotype	miRNA
OMIM	620621
Entrez	574492
RNAcentral	URS0000759A4A — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385103

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385103 — 1 exons

Exon	Start	End
ENSE00001500109	53741313	53741407

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 75.13.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.13	gold quality
monocyte	CL:0000576	74.04	gold quality
calcaneal tendon	UBERON:0003701	71.67	gold quality
lung	UBERON:0002048	71.12	gold quality
ascending aorta	UBERON:0001496	70.17	gold quality
transverse colon	UBERON:0001157	69.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.99	gold quality
esophagus mucosa	UBERON:0002469	68.45	gold quality
body of stomach	UBERON:0001161	68.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.72	gold quality
endocervix	UBERON:0000458	64.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.70	gold quality
pituitary gland	UBERON:0000007	62.24	gold quality
spleen	UBERON:0002106	60.50	gold quality
renal glomerulus	UBERON:0000074	60.43	gold quality
placenta	UBERON:0001987	52.77	gold quality
right frontal lobe	UBERON:0002810	51.22	gold quality
left testis	UBERON:0004533	44.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus (PMID:19962671)
• Down-regulation of both miR-517a and miR-517c contribute to hepatocellular carcinoma cells development through regulating Pyk2. (PMID:23142219)
• MiR-517c overexpression increased expression of the anti-angiogenic protein, sFLT1. (PMID:25799546)
• provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 GBM cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53) involved in attenuating autophagy (PMID:26553592)
• MiR-517-5p is highly expressed in placental samples of preeclampsia pregnancies, which could promote proliferative and invasive abilities of cells by inhibiting ERK/MMP-2 pathway. (PMID:30402831)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.