MIR5186

Summary

MIR5186 (microRNA 5186, HGNC:43459) is a microRNA gene on chromosome 3q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847036 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43459
Approved symbol	MIR5186
Name	microRNA 5186
Location	3q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5186
Ensembl gene	ENSG00000264330
Ensembl biotype	miRNA
Entrez	100847036
RNAcentral	URS000075B19B — ncRNA, 120 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577504

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577504 — 1 exons

Exon	Start	End
ENSE00002728501	151565876	151565995

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 80.53.

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	80.53	gold quality
monocyte	CL:0000576	78.17	gold quality
caudate nucleus	UBERON:0001873	72.83	gold quality
adrenal tissue	UBERON:0018303	71.66	gold quality
right uterine tube	UBERON:0001302	71.50	gold quality
Ammon’s horn	UBERON:0001954	70.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.12	gold quality
ascending aorta	UBERON:0001496	69.92	gold quality
blood	UBERON:0000178	69.23	gold quality
intestine	UBERON:0000160	69.10	gold quality
calcaneal tendon	UBERON:0003701	68.63	gold quality
esophagus mucosa	UBERON:0002469	67.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.04	gold quality
endometrium	UBERON:0001295	66.23	gold quality
skin of leg	UBERON:0001511	66.14	gold quality
upper lobe of left lung	UBERON:0008952	65.33	gold quality
skin of abdomen	UBERON:0001416	65.12	gold quality
right frontal lobe	UBERON:0002810	64.87	gold quality
lung	UBERON:0002048	64.57	gold quality
spleen	UBERON:0002106	64.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.09	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.37	gold quality
tibial nerve	UBERON:0001323	63.36	gold quality
adenohypophysis	UBERON:0002196	60.74	gold quality
left testis	UBERON:0004533	55.27	gold quality
testis	UBERON:0000473	53.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.