MIR5187

Summary

MIR5187 (microRNA 5187, HGNC:43523) is a microRNA gene on chromosome 1q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847090 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43523
Approved symbol	MIR5187
Name	microRNA 5187
Location	1q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5187
Ensembl gene	ENSG00000284035
Ensembl biotype	miRNA
Entrez	100847090
RNAcentral	URS0000759EA3 — ncRNA, 76 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583479 — 1 exons

Exon	Start	End
ENSE00002723653	161227186	161227261

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 87.84.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	87.84	gold quality
monocyte	CL:0000576	79.57	gold quality
tonsil	UBERON:0002372	78.97	gold quality
adrenal tissue	UBERON:0018303	76.59	gold quality
blood	UBERON:0000178	76.33	gold quality
placenta	UBERON:0001987	75.72	gold quality
muscle of leg	UBERON:0001383	74.46	gold quality
liver	UBERON:0002107	73.37	gold quality
gastrocnemius	UBERON:0001388	73.29	gold quality
endometrium	UBERON:0001295	72.98	gold quality
right lobe of liver	UBERON:0001114	72.20	gold quality
lymph node	UBERON:0000029	72.12	gold quality
islet of Langerhans	UBERON:0000006	71.94	gold quality
right atrium auricular region	UBERON:0006631	71.62	gold quality
right lung	UBERON:0002167	71.55	gold quality
gall bladder	UBERON:0002110	71.23	gold quality
heart	UBERON:0000948	70.72	gold quality
heart left ventricle	UBERON:0002084	70.53	gold quality
stomach	UBERON:0000945	70.20	gold quality
prefrontal cortex	UBERON:0000451	69.81	gold quality
smooth muscle tissue	UBERON:0001135	69.64	gold quality
body of stomach	UBERON:0001161	69.39	gold quality
urinary bladder	UBERON:0001255	69.03	gold quality
omental fat pad	UBERON:0010414	69.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.96	gold quality
lower esophagus	UBERON:0013473	68.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.93	gold quality
popliteal artery	UBERON:0002250	68.90	gold quality
right adrenal gland	UBERON:0001233	68.88	gold quality
tibial artery	UBERON:0007610	68.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.