MIR5188

Summary

MIR5188 (microRNA 5188, HGNC:43502) is a microRNA gene on chromosome 12q24.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847004 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43502
Approved symbol	MIR5188
Name	microRNA 5188
Location	12q24.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5188
Ensembl gene	ENSG00000265345
Ensembl biotype	miRNA
Entrez	100847004
RNAcentral	URS000075BE8F — ncRNA, 113 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583467

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583467 — 1 exons

Exon	Start	End
ENSE00002720206	124915547	124915659

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 95.66.

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.66	gold quality
right testis	UBERON:0004534	95.62	gold quality
testis	UBERON:0000473	90.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.66	gold quality
lower esophagus mucosa	UBERON:0035834	89.66	gold quality
sperm	CL:0000019	85.89	gold quality
right lobe of liver	UBERON:0001114	81.69	gold quality
calcaneal tendon	UBERON:0003701	79.93	gold quality
esophagus mucosa	UBERON:0002469	78.58	gold quality
amniotic fluid	UBERON:0000173	78.00	gold quality
adrenal tissue	UBERON:0018303	77.88	gold quality
monocyte	CL:0000576	77.58	gold quality
esophagus	UBERON:0001043	76.21	gold quality
gastrocnemius	UBERON:0001388	75.23	gold quality
granulocyte	CL:0000094	73.16	gold quality
vermiform appendix	UBERON:0001154	72.66	gold quality
islet of Langerhans	UBERON:0000006	71.82	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.03	gold quality
mucosa of stomach	UBERON:0001199	70.79	gold quality
left coronary artery	UBERON:0001626	70.79	gold quality
ascending aorta	UBERON:0001496	70.69	gold quality
thoracic aorta	UBERON:0001515	70.40	gold quality
left ovary	UBERON:0002119	70.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.23	gold quality
pancreatic ductal cell	CL:0002079	70.22	silver quality
body of pancreas	UBERON:0001150	70.03	gold quality
skin of abdomen	UBERON:0001416	69.64	gold quality
body of stomach	UBERON:0001161	69.57	gold quality
minor salivary gland	UBERON:0001830	69.49	gold quality
left adrenal gland	UBERON:0001234	69.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Timeless-Stimulated miR-5188-FOXO1/beta-Catenin-c-Jun Feedback Loop Promotes Stemness via Ubiquitination of beta-Catenin in Breast Cancer. (PMID:31604679)
• miR-5188 augments glioma growth, migration and invasion through an SP1-modulated FOXO1-PI3K/AKT-c-JUN-positive feedback circuit. (PMID:32902145)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.