MIR5189

Summary

MIR5189 (microRNA 5189, HGNC:43515) is a microRNA gene on chromosome 16q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847057 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43515
Approved symbol	MIR5189
Name	microRNA 5189
Location	16q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5189
Ensembl gene	ENSG00000263456
Ensembl biotype	miRNA
Entrez	100847057
RNAcentral	URS000075DEEB — miRNA, 114 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577370

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577370 — 1 exons

Exon	Start	End
ENSE00002690600	88468918	88469031

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 84.04.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	84.04	gold quality
blood	UBERON:0000178	78.26	gold quality
fundus of stomach	UBERON:0001160	77.67	gold quality
bone marrow	UBERON:0002371	74.52	gold quality
gastrocnemius	UBERON:0001388	74.25	gold quality
body of pancreas	UBERON:0001150	72.55	gold quality
stomach	UBERON:0000945	72.03	gold quality
body of stomach	UBERON:0001161	71.38	gold quality
gall bladder	UBERON:0002110	70.75	gold quality
tibial artery	UBERON:0007610	70.62	gold quality
colon	UBERON:0001155	70.32	gold quality
left adrenal gland cortex	UBERON:0035825	70.05	gold quality
vagina	UBERON:0000996	69.52	gold quality
left adrenal gland	UBERON:0001234	68.64	gold quality
liver	UBERON:0002107	68.30	gold quality
tibial nerve	UBERON:0001323	67.64	gold quality
transverse colon	UBERON:0001157	67.62	gold quality
right atrium auricular region	UBERON:0006631	67.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.58	gold quality
heart	UBERON:0000948	67.56	gold quality
granulocyte	CL:0000094	67.53	gold quality
intestine	UBERON:0000160	67.06	gold quality
body of uterus	UBERON:0009853	67.01	gold quality
left coronary artery	UBERON:0001626	66.71	gold quality
esophagus mucosa	UBERON:0002469	66.16	gold quality
right lobe of liver	UBERON:0001114	66.04	gold quality
skin of abdomen	UBERON:0001416	66.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.85	gold quality
caudate nucleus	UBERON:0001873	65.65	gold quality
omental fat pad	UBERON:0010414	65.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Role and Mechanism of mir-5189-3p in Deep Vein Thrombosis of Lower Extremities. (PMID:34416282)
• MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma. (PMID:37656330)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.