MIR518A1

Summary

MIR518A1 (microRNA 518a-1, HGNC:32120) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574488 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32120
Approved symbol	MIR518A1
Name	microRNA 518a-1
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518a-1
Ensembl gene	ENSG00000207803
Ensembl biotype	miRNA
OMIM	620617
Entrez	574488
RNAcentral	URS0000724CB9 — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385068

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385068 — 1 exons

Exon	Start	End
ENSE00001808940	53731006	53731090

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 75.50.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	75.50	gold quality
tibial artery	UBERON:0007610	71.07	gold quality
omental fat pad	UBERON:0010414	69.20	gold quality
transverse colon	UBERON:0001157	68.14	gold quality
thoracic aorta	UBERON:0001515	67.57	gold quality
esophagus mucosa	UBERON:0002469	66.75	gold quality
upper lobe of left lung	UBERON:0008952	65.69	gold quality
gastrocnemius	UBERON:0001388	65.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.07	gold quality
skin of abdomen	UBERON:0001416	64.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.14	gold quality
body of uterus	UBERON:0009853	63.91	gold quality
endocervix	UBERON:0000458	63.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.61	gold quality
pituitary gland	UBERON:0000007	60.45	gold quality
small intestine Peyer’s patch	UBERON:0003454	53.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells.[miR-518a-5p] (PMID:24559209)
• miR-518a-5p was downregulated in imatinib-resistant gastrointestinal stromal tumors (GISTs), and the expression of miR-518a-5p was confirmed with good concordance between real-time PCR and miRNA microarray results. Luciferase reporter assays indicated that miR-518a-5p bound to the PIK3C2A 3’UTR. (PMID:26950487)
• Study found that a cysteine-rich 61 (CCN1)-induced increase in Monocyte chemoattractant protein-1 expression is mediated by the MAPK signaling pathway and that miR-518a-5p expression was negatively regulated by CCN1 via the MAPK cascade. (PMID:28341837)
• Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma. (PMID:32600091)
• MIR-518a-5p Targets ZEB2 to Suppress the Migration and Invasion of Breast-cancer Cells. (PMID:35986741)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.