MIR518A2

Summary

MIR518A2 (microRNA 518a-2, HGNC:32123) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574491 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32123
Approved symbol	MIR518A2
Name	microRNA 518a-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518a-2
Ensembl gene	ENSG00000207699
Ensembl biotype	miRNA
OMIM	620620
Entrez	574491
RNAcentral	URS0000647988 — miRNA, 87 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384966 — 1 exons

Exon	Start	End
ENSE00001806881	53739333	53739419

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.36.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.36	gold quality
skin of abdomen	UBERON:0001416	75.90	gold quality
stomach	UBERON:0000945	72.68	gold quality
tibial artery	UBERON:0007610	71.37	gold quality
ascending aorta	UBERON:0001496	69.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.54	gold quality
minor salivary gland	UBERON:0001830	68.44	gold quality
omental fat pad	UBERON:0010414	67.63	gold quality
body of stomach	UBERON:0001161	66.53	gold quality
body of uterus	UBERON:0009853	64.23	gold quality
esophagus mucosa	UBERON:0002469	63.93	gold quality
endocervix	UBERON:0000458	63.59	gold quality
prostate gland	UBERON:0002367	62.23	gold quality
left uterine tube	UBERON:0001303	60.97	gold quality
tibial nerve	UBERON:0001323	60.68	gold quality
spleen	UBERON:0002106	59.35	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
right testis	UBERON:0004534	48.52	gold quality
left testis	UBERON:0004533	42.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells.[miR-518a-5p] (PMID:24559209)
• miR-518a-5p was downregulated in imatinib-resistant gastrointestinal stromal tumors (GISTs), and the expression of miR-518a-5p was confirmed with good concordance between real-time PCR and miRNA microarray results. Luciferase reporter assays indicated that miR-518a-5p bound to the PIK3C2A 3’UTR. (PMID:26950487)
• Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma. (PMID:32600091)
• MIR-518a-5p Targets ZEB2 to Suppress the Migration and Invasion of Breast-cancer Cells. (PMID:35986741)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.