MIR518B

Summary

MIR518B (microRNA 518b, HGNC:32106) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574474 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32106
Approved symbol	MIR518B
Name	microRNA 518b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518b
Ensembl gene	ENSG00000207862
Ensembl biotype	miRNA
OMIM	620596
Entrez	574474
RNAcentral	URS000075A310 — miRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385127

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385127 — 1 exons

Exon	Start	End
ENSE00001807042	53702737	53702819

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 88.36.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal glomerulus	UBERON:0000074	88.36	gold quality
monocyte	CL:0000576	75.58	gold quality
gastrocnemius	UBERON:0001388	70.47	gold quality
right lobe of liver	UBERON:0001114	69.54	gold quality
placenta	UBERON:0001987	66.12	gold quality
esophagus mucosa	UBERON:0002469	65.92	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.72	gold quality
right ovary	UBERON:0002118	63.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.69	gold quality
spleen	UBERON:0002106	58.14	gold quality
right testis	UBERON:0004534	52.77	gold quality
corpus callosum	UBERON:0002336	47.09	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• hsa-miR-126 and hsa-miR-518b are differentially expressed in esophageal squamous carcinoma, and might play important roles in carcinogenesis and progression. (PMID:21269950)
• underexpressed in complete hydatidiform mole (PMID:22672989)
• Taken together, these data show that GA induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 cells. (PMID:24173143)
• These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. (PMID:24383669)
• Decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestational age may be a predictive marker for the risks of alert bleeding later and massive hemorrhage at delivery. (PMID:26040940)
• These findings indicated that miR-518b may function as a tumor suppressor by targeting PDGFRB in the occurrence and development of GBM. (PMID:28849154)
• Compared with those in control group, the expressions of OPN and VEGF proteins in placenta accreta group were significantly increased. There were positive correlations between miR-518b and levels of OPN, VEGF mRNA. The high expression of miR-518b may lead to the development of placenta accreta through upregulating the transcription and protein expression of downstream VEGF and OPN. (PMID:30657542)
• miR-518b and miR-338-3p were differentially expressed in placentas between acute chorioamnionitis cases and controls. (PMID:31174625)
• Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrestdagger. (PMID:31291448)
• Placenta-specific plasma miR518b is a potential biomarker for preeclampsia. (PMID:32092293)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.