MIR518C

Summary

MIR518C (microRNA 518c, HGNC:32109) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574477 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32109
Approved symbol	MIR518C
Name	microRNA 518c
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518c
Ensembl gene	ENSG00000283490
Ensembl biotype	miRNA
OMIM	620598
Entrez	574477
RNAcentral	URS000075EEDB — miRNA, 101 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384822

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384822 — 1 exons

Exon	Start	End
ENSE00001499829	53708735	53708835

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 79.11.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.11	gold quality
renal glomerulus	UBERON:0000074	75.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.54	gold quality
placenta	UBERON:0001987	73.18	gold quality
thoracic aorta	UBERON:0001515	70.72	gold quality
skin of leg	UBERON:0001511	67.73	gold quality
thoracic mammary gland	UBERON:0005200	67.00	gold quality
skin of abdomen	UBERON:0001416	66.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.79	gold quality
right adrenal gland	UBERON:0001233	66.78	gold quality
right frontal lobe	UBERON:0002810	63.69	gold quality
esophagus mucosa	UBERON:0002469	63.61	gold quality
lung	UBERON:0002048	61.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Results suggest that MicroRNA 518 (MIR518) harbors variants that increase the risk of essential and affect blood pressure homeostasis as well as efficacy of antihypertensive agents in a Chinese population. (PMID:24687999)
• High miR518 expression is associated with hyper-androgenic Polycystic Ovary Syndrome. (PMID:26771704)
• miR-518 acted as a new tumor suppressor by targeting MDM2 gene and trigger apoptosis in vivo and in vitro. (PMID:29793321)
• Serum miR-518e-5p is expressed early in secondary imatinib-resistant gastrointestinal stromal tumor patients. (PMID:30541960)
• MicroRNA-518-3p suppresses cell proliferation, invasiveness, and migration in colorectal cancer via targeting TRIP4. (PMID:32298598)
• Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells. (PMID:32423468)
• Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS. (PMID:35974445)
• LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis. (PMID:37718780)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.