MIR518D

Summary

MIR518D (microRNA 518d, HGNC:32121) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574489 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32121
Approved symbol	MIR518D
Name	microRNA 518d
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518d
Ensembl gene	ENSG00000283330
Ensembl biotype	miRNA
OMIM	620618
Entrez	574489
RNAcentral	URS00006DAC3B — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385014

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385014 — 1 exons

Exon	Start	End
ENSE00001806923	53734877	53734963

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 78.21.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	78.21	gold quality
monocyte	CL:0000576	76.14	gold quality
heart left ventricle	UBERON:0002084	72.30	gold quality
blood	UBERON:0000178	68.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.00	gold quality
ascending aorta	UBERON:0001496	67.98	gold quality
body of pancreas	UBERON:0001150	66.70	gold quality
esophagus mucosa	UBERON:0002469	66.64	gold quality
skin of leg	UBERON:0001511	65.74	gold quality
skin of abdomen	UBERON:0001416	65.41	gold quality
lower esophagus mucosa	UBERON:0035834	65.12	gold quality
tibial nerve	UBERON:0001323	63.91	gold quality
myometrium	UBERON:0001296	63.89	gold quality
prostate gland	UBERON:0002367	62.22	gold quality
spleen	UBERON:0002106	61.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MicroRNA-518d regulates PPARalpha protein expression in the placentas of females with gestational diabetes mellitus. (PMID:24639097)
• LIN28B and miR-518d-5p could regulate DLL3-mediated cell proliferation and migration. (PMID:31079917)
• Regulation and Mechanism of miR-518d through the PPARalpha-Mediated NF-kappaB Pathway in the Development of Gestational Diabetes Mellitus. (PMID:33123597)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.