MIR518E

Summary

MIR518E (microRNA 518e, HGNC:32119) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574487 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32119
Approved symbol	MIR518E
Name	microRNA 518e
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518e
Ensembl gene	ENSG00000207987
Ensembl biotype	miRNA
OMIM	620616
Entrez	574487
RNAcentral	URS0000651BF7 — miRNA, 88 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385252

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385252 — 1 exons

Exon	Start	End
ENSE00001500258	53729838	53729925

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 82.54.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.54	gold quality
renal glomerulus	UBERON:0000074	74.40	gold quality
skin of abdomen	UBERON:0001416	72.34	gold quality
ascending aorta	UBERON:0001496	72.33	gold quality
blood	UBERON:0000178	70.37	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.42	gold quality
esophagus mucosa	UBERON:0002469	68.22	gold quality
tibial artery	UBERON:0007610	68.19	gold quality
body of pancreas	UBERON:0001150	68.04	gold quality
skin of leg	UBERON:0001511	67.26	gold quality
body of stomach	UBERON:0001161	66.10	gold quality
right adrenal gland	UBERON:0001233	66.02	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.89	gold quality
thoracic mammary gland	UBERON:0005200	64.18	gold quality
body of uterus	UBERON:0009853	64.17	gold quality
tibial nerve	UBERON:0001323	62.25	gold quality
transverse colon	UBERON:0001157	61.83	gold quality
left ovary	UBERON:0002119	60.07	gold quality
placenta	UBERON:0001987	57.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study shows elevated levels of miR-147a and miR-518e in forebrains of two different groups of progressive supranuclear palsy patients. The two miRs appear to increase disease risk by depressing target genes that play major roles in various cellular processes and might therefore be targets for therapeutic interventions. (PMID:27052995)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.