MIR518F

Summary

MIR518F (microRNA 518f, HGNC:32104) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574472 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32104
Approved symbol	MIR518F
Name	microRNA 518f
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-518f
Ensembl gene	ENSG00000207706
Ensembl biotype	miRNA
OMIM	620594
Entrez	574472
RNAcentral	URS000062EA49 — miRNA, 87 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384973

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384973 — 1 exons

Exon	Start	End
ENSE00001808717	53700015	53700101

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 77.08.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	77.08	gold quality
esophagus mucosa	UBERON:0002469	77.00	gold quality
monocyte	CL:0000576	76.07	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.02	gold quality
blood	UBERON:0000178	69.80	gold quality
gastrocnemius	UBERON:0001388	69.32	gold quality
right atrium auricular region	UBERON:0006631	68.41	gold quality
renal glomerulus	UBERON:0000074	67.41	gold quality
ascending aorta	UBERON:0001496	66.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.37	gold quality
left ovary	UBERON:0002119	65.39	gold quality
myometrium	UBERON:0001296	63.89	gold quality
thoracic mammary gland	UBERON:0005200	63.57	gold quality
tibial nerve	UBERON:0001323	62.27	gold quality
spleen	UBERON:0002106	57.96	gold quality
placenta	UBERON:0001987	54.72	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
left testis	UBERON:0004533	43.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Placental expression of miR-517-5p and miR-518f-5p: Fetal sex-specific relations with human fetoplacental growth. (PMID:34992034)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.