MIR5190

Summary

MIR5190 (microRNA 5190, HGNC:43549) is a microRNA gene on chromosome 18p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847080 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43549
Approved symbol	MIR5190
Name	microRNA 5190
Location	18p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5190
Ensembl gene	ENSG00000266146
Ensembl biotype	miRNA
Entrez	100847080
RNAcentral	URS000075ABEE — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581537

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581537 — 1 exons

Exon	Start	End
ENSE00002732370	13459947	13460026

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 97.07.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.07	gold quality
liver	UBERON:0002107	89.30	gold quality
calcaneal tendon	UBERON:0003701	86.21	gold quality
lung	UBERON:0002048	82.82	gold quality
blood	UBERON:0000178	82.02	gold quality
adrenal tissue	UBERON:0018303	81.47	gold quality
muscle of leg	UBERON:0001383	79.81	gold quality
kidney	UBERON:0002113	77.00	gold quality
stomach	UBERON:0000945	76.49	gold quality
monocyte	CL:0000576	75.36	gold quality
heart left ventricle	UBERON:0002084	73.12	gold quality
gastrocnemius	UBERON:0001388	72.44	gold quality
heart	UBERON:0000948	71.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.22	gold quality
myometrium	UBERON:0001296	69.20	gold quality
corpus callosum	UBERON:0002336	69.06	gold quality
adult mammalian kidney	UBERON:0000082	68.96	gold quality
endometrium	UBERON:0001295	68.91	gold quality
right adrenal gland	UBERON:0001233	68.76	gold quality
right lobe of liver	UBERON:0001114	68.04	gold quality
amygdala	UBERON:0001876	67.62	gold quality
substantia nigra	UBERON:0002038	67.45	gold quality
apex of heart	UBERON:0002098	67.27	gold quality
colon	UBERON:0001155	67.15	gold quality
left adrenal gland	UBERON:0001234	67.15	gold quality
intestine	UBERON:0000160	66.89	gold quality
ascending aorta	UBERON:0001496	66.86	gold quality
body of stomach	UBERON:0001161	66.59	gold quality
thoracic aorta	UBERON:0001515	66.50	gold quality
omental fat pad	UBERON:0010414	66.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circulating mir-5190 was negatively correlated with HbA1c in Type 1 diabetics. (PMID:29453204)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.