MIR5191

Summary

MIR5191 (microRNA 5191, HGNC:43497) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847050 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43497
Approved symbol	MIR5191
Name	microRNA 5191
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5191
Ensembl gene	ENSG00000264802
Ensembl biotype	miRNA
Entrez	100847050
RNAcentral	URS000075DFB5 — miRNA, 120 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577455

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577455 — 1 exons

Exon	Start	End
ENSE00002695312	201719508	201719627

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 77.20.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	77.20	gold quality
blood	UBERON:0000178	75.01	gold quality
kidney	UBERON:0002113	74.16	gold quality
lung	UBERON:0002048	73.11	gold quality
left coronary artery	UBERON:0001626	72.16	gold quality
islet of Langerhans	UBERON:0000006	71.94	gold quality
stomach	UBERON:0000945	70.85	gold quality
ascending aorta	UBERON:0001496	70.76	gold quality
tibial artery	UBERON:0007610	70.76	gold quality
thoracic mammary gland	UBERON:0005200	70.67	gold quality
gastrocnemius	UBERON:0001388	70.42	gold quality
thoracic aorta	UBERON:0001515	70.12	gold quality
adrenal tissue	UBERON:0018303	70.02	gold quality
right atrium auricular region	UBERON:0006631	68.76	gold quality
body of pancreas	UBERON:0001150	68.26	gold quality
heart left ventricle	UBERON:0002084	68.02	gold quality
esophagus mucosa	UBERON:0002469	67.94	gold quality
heart	UBERON:0000948	67.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.71	gold quality
left ovary	UBERON:0002119	67.34	gold quality
body of stomach	UBERON:0001161	66.78	gold quality
spleen	UBERON:0002106	66.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.90	gold quality
minor salivary gland	UBERON:0001830	65.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.86	gold quality
caudate nucleus	UBERON:0001873	65.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.56	gold quality
intestine	UBERON:0000160	65.42	gold quality
skin of abdomen	UBERON:0001416	65.41	gold quality
Ammon’s horn	UBERON:0001954	65.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-5191 acts as a tumor suppressor in salivary adenoid cystic carcinoma by targeting Notch-2. (PMID:33694237)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.