MIR5192

Summary

MIR5192 (microRNA 5192, HGNC:43473) is a microRNA gene on chromosome 2p15.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847087 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43473
Approved symbol	MIR5192
Name	microRNA 5192
Location	2p15
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5192
Ensembl gene	ENSG00000266097
Ensembl biotype	miRNA
Entrez	100847087
RNAcentral	URS000075B0A4 — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579892

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579892 — 1 exons

Exon	Start	End
ENSE00002731074	62205826	62205917

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 89.87.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.87	gold quality
bone marrow	UBERON:0002371	83.85	gold quality
adrenal tissue	UBERON:0018303	83.05	gold quality
blood	UBERON:0000178	79.57	gold quality
calcaneal tendon	UBERON:0003701	78.97	gold quality
monocyte	CL:0000576	78.32	gold quality
liver	UBERON:0002107	76.81	gold quality
kidney	UBERON:0002113	76.66	gold quality
body of pancreas	UBERON:0001150	73.98	gold quality
adult mammalian kidney	UBERON:0000082	73.88	gold quality
islet of Langerhans	UBERON:0000006	73.85	gold quality
stomach	UBERON:0000945	73.58	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.76	gold quality
myometrium	UBERON:0001296	72.37	gold quality
gastrocnemius	UBERON:0001388	72.35	gold quality
heart left ventricle	UBERON:0002084	72.19	gold quality
prefrontal cortex	UBERON:0000451	71.69	gold quality
body of stomach	UBERON:0001161	70.88	gold quality
left coronary artery	UBERON:0001626	70.80	gold quality
heart	UBERON:0000948	70.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.59	gold quality
endometrium	UBERON:0001295	69.22	gold quality
lung	UBERON:0002048	68.98	gold quality
right coronary artery	UBERON:0001625	68.90	gold quality
putamen	UBERON:0001874	68.75	gold quality
multicellular organism	UBERON:0000468	68.62	gold quality
ascending aorta	UBERON:0001496	68.37	gold quality
intestine	UBERON:0000160	68.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.04	gold quality
adenohypophysis	UBERON:0002196	67.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.