MIR5193

Summary

MIR5193 (microRNA 5193, HGNC:43534) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847079 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43534
Approved symbol	MIR5193
Name	microRNA 5193
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5193
Ensembl gene	ENSG00000283726
Ensembl biotype	miRNA
Entrez	100847079
RNAcentral	URS000075E648 — ncRNA, 109 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584510

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584510 — 1 exons

Exon	Start	End
ENSE00002722323	49806137	49806245

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 79.61.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	79.61	gold quality
blood	UBERON:0000178	75.84	gold quality
vermiform appendix	UBERON:0001154	75.28	gold quality
islet of Langerhans	UBERON:0000006	72.99	gold quality
muscle of leg	UBERON:0001383	71.87	gold quality
gastrocnemius	UBERON:0001388	71.53	gold quality
body of pancreas	UBERON:0001150	68.72	gold quality
liver	UBERON:0002107	67.94	gold quality
right adrenal gland cortex	UBERON:0035827	67.34	gold quality
bone marrow	UBERON:0002371	66.32	gold quality
adrenal tissue	UBERON:0018303	66.13	gold quality
urinary bladder	UBERON:0001255	65.87	gold quality
right lobe of thyroid gland	UBERON:0001119	65.50	gold quality
popliteal artery	UBERON:0002250	65.32	gold quality
tibial artery	UBERON:0007610	65.30	gold quality
kidney	UBERON:0002113	65.27	gold quality
prostate gland	UBERON:0002367	65.21	gold quality
sural nerve	UBERON:0015488	64.74	gold quality
lower esophagus	UBERON:0013473	64.49	gold quality
stomach	UBERON:0000945	64.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.45	gold quality
body of stomach	UBERON:0001161	64.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.26	gold quality
adult mammalian kidney	UBERON:0000082	63.78	gold quality
right lobe of liver	UBERON:0001114	63.62	gold quality
esophagus	UBERON:0001043	63.43	gold quality
omental fat pad	UBERON:0010414	63.36	gold quality
putamen	UBERON:0001874	63.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Human miR-5193 Triggers Gene Silencing in Multiple Genotypes of Hepatitis B Virus (PMID:26456535)
• TRIM11 was upregulated in prostate cancer tissue and was associated with reduced prognosis. TRIM11 expression increased cell proliferation in vitro and was downregulated by miR-5193. (PMID:30608062)
• miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11. (PMID:32823233)
• TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer. (PMID:37248611)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.