MIR5194

Summary

MIR5194 (microRNA 5194, HGNC:43498) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847051 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43498
Approved symbol	MIR5194
Name	microRNA 5194
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5194
Ensembl gene	ENSG00000264653
Ensembl biotype	miRNA
Entrez	100847051
RNAcentral	URS000075E31E — ncRNA, 120 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582634

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582634 — 1 exons

Exon	Start	End
ENSE00002723864	130008334	130008453

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 91.45.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.45	gold quality
blood	UBERON:0000178	84.09	gold quality
monocyte	CL:0000576	83.74	gold quality
corpus callosum	UBERON:0002336	81.60	gold quality
bone marrow	UBERON:0002371	79.77	gold quality
adult mammalian kidney	UBERON:0000082	78.99	gold quality
adrenal tissue	UBERON:0018303	76.98	gold quality
prefrontal cortex	UBERON:0000451	75.49	gold quality
stomach	UBERON:0000945	74.21	gold quality
lower esophagus mucosa	UBERON:0035834	73.98	gold quality
kidney	UBERON:0002113	73.48	gold quality
gastrocnemius	UBERON:0001388	72.80	gold quality
multicellular organism	UBERON:0000468	72.70	gold quality
tibial artery	UBERON:0007610	70.78	gold quality
adrenal gland	UBERON:0002369	69.74	gold quality
right lobe of liver	UBERON:0001114	69.47	gold quality
left adrenal gland cortex	UBERON:0035825	69.10	gold quality
liver	UBERON:0002107	68.88	gold quality
lung	UBERON:0002048	68.62	gold quality
heart	UBERON:0000948	68.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.41	gold quality
body of pancreas	UBERON:0001150	68.25	gold quality
endometrium	UBERON:0001295	68.23	gold quality
left adrenal gland	UBERON:0001234	68.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.94	gold quality
vagina	UBERON:0000996	67.72	gold quality
calcaneal tendon	UBERON:0003701	67.62	gold quality
body of stomach	UBERON:0001161	67.58	gold quality
colon	UBERON:0001155	67.25	gold quality
omental fat pad	UBERON:0010414	67.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression. (PMID:35256570)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.