MIR5196

Summary

MIR5196 (microRNA 5196, HGNC:43542) is a microRNA gene on chromosome 19q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847070 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43542
Approved symbol	MIR5196
Name	microRNA 5196
Location	19q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5196
Ensembl gene	ENSG00000284034
Ensembl biotype	miRNA
Entrez	100847070
RNAcentral	URS000075E0F8 — ncRNA, 115 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578146

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578146 — 1 exons

Exon	Start	End
ENSE00002710658	35345513	35345627

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 88.97.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.97	gold quality
islet of Langerhans	UBERON:0000006	83.44	gold quality
monocyte	CL:0000576	78.06	gold quality
blood	UBERON:0000178	76.05	gold quality
left ovary	UBERON:0002119	74.94	gold quality
bone marrow	UBERON:0002371	74.42	gold quality
spleen	UBERON:0002106	74.25	gold quality
ovary	UBERON:0000992	74.15	gold quality
vermiform appendix	UBERON:0001154	73.07	gold quality
lymph node	UBERON:0000029	72.80	gold quality
placenta	UBERON:0001987	72.80	gold quality
gastrocnemius	UBERON:0001388	72.24	gold quality
right ovary	UBERON:0002118	71.46	gold quality
body of pancreas	UBERON:0001150	70.87	gold quality
prefrontal cortex	UBERON:0000451	70.69	gold quality
heart left ventricle	UBERON:0002084	70.42	gold quality
skin of leg	UBERON:0001511	70.21	gold quality
left adrenal gland	UBERON:0001234	70.03	gold quality
Ammon’s horn	UBERON:0001954	70.02	gold quality
right lobe of liver	UBERON:0001114	69.98	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.19	gold quality
tibial artery	UBERON:0007610	69.05	gold quality
amygdala	UBERON:0001876	68.92	gold quality
tonsil	UBERON:0002372	68.74	gold quality
body of stomach	UBERON:0001161	68.32	gold quality
kidney	UBERON:0002113	67.83	gold quality
anterior cingulate cortex	UBERON:0009835	67.67	gold quality
transverse colon	UBERON:0001157	67.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The results show that expression of circulating microRNA-5196 was correlated with Systemic Sclerosis parameters. The study also suggests that microRNA-5196 can be used as a potential biomarker for Systemic Sclerosis. (PMID:28639412)
• MiRNA-5196 expression is significantly higher in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS)before necrosis factor (TNF)-alpha therapy than in those following anti-TNF-alpha therapy and healthy controls. Changes in miRNA-5196 expression positively correlate with delta disease activity score following TNF-alpha therapy. (PMID:29744553)
• Role of rs10406069 in miR-5196 in hyperdiploid childhood acute lymphoblastic leukemia. (PMID:33245684)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.