MIR519A1

Summary

MIR519A1 (microRNA 519a-1, HGNC:32128) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574496 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32128
Approved symbol	MIR519A1
Name	microRNA 519a-1
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-519a-1
Ensembl gene	ENSG00000207992
Ensembl biotype	miRNA
OMIM	620624
Entrez	574496
RNAcentral	URS000075A42F — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385257 — 1 exons

Exon	Start	End
ENSE00001808052	53752397	53752481

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 71.19.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	71.19	gold quality
body of stomach	UBERON:0001161	68.30	gold quality
esophagus mucosa	UBERON:0002469	66.25	gold quality
blood	UBERON:0000178	64.51	gold quality
ascending aorta	UBERON:0001496	63.78	gold quality
left ovary	UBERON:0002119	63.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.13	gold quality
lung	UBERON:0002048	58.65	gold quality
spleen	UBERON:0002106	57.19	gold quality
left testis	UBERON:0004533	46.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• the growth-promoting effects of antisense miR-519 required the presence of HuR (PMID:19088191)
• two stem cell microRNA gene clusters C19MC (miR-512-5p, miR-517a, and miR-519a)and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas (PMID:20209130)
• Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumors. (PMID:21083603)
• MicroRNA-519a may function as a tumour suppressor by inhibiting HuR expression, and may serve as a therapeutic target for laryngeal squamous cell carcinoma. (PMID:24300127)
• MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. (PMID:24752803)
• miR-519a promotes tumor growth of hepatocellular carcinoma by targeting PTEN-mediated PI3K/AKT pathway (PMID:26708293)
• The results from these procedures revealed eIF4H to be one of the targets of miR-519d. Downregulated eIF4H was analogous to the overexpressed miR-519d obtained from miR-519d agomir and si-eIF4H transfection. In summary, it can be concluded that miR-519d targets eIF4H in lung adenocarcinoma to inhibit cell proliferation and invasion (PMID:28351305)
• analysis of microRNA-17, microRNA-181a, and microRNA-519a in the villous tree in preeclampsia (PMID:30353329)
• Low expression level of miR-519 was closely correlated with the poor prognosis for overall survival of esophageal squamous cell carcinoma (ESCC) patients or patients who received radiotherapy. Functional assays indicated that upregulation of miR-519 made ESCC cells more sensitive to gamma-ray radiation and facilitated ESCC cell apoptosis triggered by irradiation treatment via regulating DNA response. (PMID:31529206)
• MiR-519d-3p in Trophoblastic Cells: Effects, Targets and Transfer to Allogeneic Immune Cells via Extracellular Vesicles. (PMID:32422900)
• Restored microRNA-519a enhances the radiosensitivity of non-small cell lung cancer via suppressing EphA2. (PMID:33414521)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.