MIR519A2

Summary

MIR519A2 (microRNA 519a-2, HGNC:32132) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574500 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32132
Approved symbol	MIR519A2
Name	microRNA 519a-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-519a-2
Ensembl gene	ENSG00000284362
Ensembl biotype	miRNA
OMIM	620628
Entrez	574500
RNAcentral	URS0000007095 — miRNA, 87 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384990

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384990 — 1 exons

Exon	Start	End
ENSE00001808732	53762344	53762430

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 77.91.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	77.91	gold quality
right ovary	UBERON:0002118	64.94	gold quality
blood	UBERON:0000178	50.82	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• the growth-promoting effects of antisense miR-519 required the presence of HuR (PMID:19088191)
• Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumors. (PMID:21083603)
• analysis of microRNA-17, microRNA-181a, and microRNA-519a in the villous tree in preeclampsia (PMID:30353329)
• Low expression level of miR-519 was closely correlated with the poor prognosis for overall survival of esophageal squamous cell carcinoma (ESCC) patients or patients who received radiotherapy. Functional assays indicated that upregulation of miR-519 made ESCC cells more sensitive to gamma-ray radiation and facilitated ESCC cell apoptosis triggered by irradiation treatment via regulating DNA response. (PMID:31529206)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.