MIR519B

Summary

MIR519B (microRNA 519b, HGNC:32101) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574469 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32101
Approved symbol	MIR519B
Name	microRNA 519b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-519b
Ensembl gene	ENSG00000207825
Ensembl biotype	miRNA
OMIM	620591
Entrez	574469
RNAcentral	URS000075EA92 — miRNA, 81 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385090

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385090 — 1 exons

Exon	Start	End
ENSE00001500096	53695213	53695293

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 83.86.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0133 / max 4.2692, expressed in 9 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177382	0.0133	9

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	83.86	gold quality
monocyte	CL:0000576	76.70	gold quality
blood	UBERON:0000178	69.43	gold quality
thoracic aorta	UBERON:0001515	68.66	gold quality
ascending aorta	UBERON:0001496	68.45	gold quality
granulocyte	CL:0000094	67.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.27	gold quality
esophagus mucosa	UBERON:0002469	66.12	gold quality
thoracic mammary gland	UBERON:0005200	64.81	gold quality
left ovary	UBERON:0002119	64.70	gold quality
endocervix	UBERON:0000458	63.55	gold quality
transverse colon	UBERON:0001157	63.49	gold quality
spleen	UBERON:0002106	61.60	gold quality
right testis	UBERON:0004534	51.71	gold quality
left testis	UBERON:0004533	48.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• the growth-promoting effects of antisense miR-519 required the presence of HuR (PMID:19088191)
• Increased amount of truncated neurokinin-1 in breast cancer cells is due to enhanced transcription and suppressed translation of NK1-FL by miR-519b to reduced tumor growth. (PMID:22981979)
• TGFB1 stimulated the expression of HO-1 via activating the PLCgamma/PKCalpha pathway and suppressing the downstream expression of miRNA-519b. (PMID:28423042)
• miR-519b-3p directly binds to the 3’ UTR of ARID4B mRNA whose expression was inversely correlated with miR-519b-3p expression. (PMID:29477868)
• Low expression level of miR-519 was closely correlated with the poor prognosis for overall survival of esophageal squamous cell carcinoma (ESCC) patients or patients who received radiotherapy. Functional assays indicated that upregulation of miR-519 made ESCC cells more sensitive to gamma-ray radiation and facilitated ESCC cell apoptosis triggered by irradiation treatment via regulating DNA response. (PMID:31529206)
• miR-519b-3p binds to LINC01419 and has a role in upregulating RCCD1 in lung adenocarcinoma cells (PMID:31582214)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.