MIR519C

Summary

MIR519C (microRNA 519c, HGNC:32098) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574466 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32098
Approved symbol	MIR519C
Name	microRNA 519c
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-519c
Ensembl gene	ENSG00000207788
Ensembl biotype	miRNA
OMIM	620587
Entrez	574466
RNAcentral	URS00006D6710 — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385053

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385053 — 1 exons

Exon	Start	End
ENSE00001808124	53686469	53686555

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 74.58.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	74.58	gold quality
adrenal tissue	UBERON:0018303	73.97	gold quality
ascending aorta	UBERON:0001496	69.99	gold quality
endocervix	UBERON:0000458	69.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.57	gold quality
esophagus mucosa	UBERON:0002469	66.99	gold quality
skin of abdomen	UBERON:0001416	65.41	gold quality
spleen	UBERON:0002106	64.55	gold quality
vagina	UBERON:0000996	63.84	gold quality
ectocervix	UBERON:0012249	63.09	gold quality
amygdala	UBERON:0001876	62.73	gold quality
prostate gland	UBERON:0002367	61.05	gold quality
body of stomach	UBERON:0001161	60.34	gold quality
left testis	UBERON:0004533	48.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• the binding of a putative miRNA at the 3’UTR of ABCG2 suppresses the expression of ABCG2. (PMID:18573883)
• the growth-promoting effects of antisense miR-519 required the presence of HuR (PMID:19088191)
• In ABCG2-overexpressing drug-resistant cells, hsa-miR-519c is unable to affect ABCG2 expression because the mRNA lacks its binding site, whereas hsa-miR-520h is sequestered and unable to limit ABCG2 expression. (PMID:19825807)
• miR-519c is a pivotal regulator of tumor angiogenesis and that microenvironmental HGF contributes to regulating miR-519c biogenesis in cancer cells. (PMID:20233879)
• micro-RNA mir-519c (and -328) had greater impact on ABCG2 expression than mir-520h in breast cancer cells. (PMID:21219875)
• Hsa-mir-519c and hsa-mir-520 directly regulate expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. (PMID:22887864)
• By an interplay between miR-519c, HuR and the length of the 3’ untranslated region (UTR) of ABCG2. (PMID:26386386)
• miR-519c-3p functions as a tumor promotor in regulating the growth and metastasis of hepatocellular carcinoma by targeting BTG3. (PMID:31387005)
• Low expression level of miR-519 was closely correlated with the poor prognosis for overall survival of esophageal squamous cell carcinoma (ESCC) patients or patients who received radiotherapy. Functional assays indicated that upregulation of miR-519 made ESCC cells more sensitive to gamma-ray radiation and facilitated ESCC cell apoptosis triggered by irradiation treatment via regulating DNA response. (PMID:31529206)
• Inhibiting lncRNA NEAT1 facilitates the sensitization of melanoma cells to cisplatin through modulating the miR-519c-3p-MeCP2 axis. (PMID:36841132)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.