MIR519E

Summary

MIR519E (microRNA 519e, HGNC:32095) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574463 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32095
Approved symbol	MIR519E
Name	microRNA 519e
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-519e
Ensembl gene	ENSG00000207810
Ensembl biotype	miRNA
OMIM	620575
Entrez	574463
RNAcentral	URS00006B3851 — miRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385075

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385075 — 1 exons

Exon	Start	End
ENSE00001500081	53679940	53680023

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 82.42.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.42	gold quality
adipose tissue	UBERON:0001013	76.74	gold quality
placenta	UBERON:0001987	75.24	gold quality
body of stomach	UBERON:0001161	68.33	gold quality
transverse colon	UBERON:0001157	65.12	gold quality
endocervix	UBERON:0000458	63.46	gold quality
prostate gland	UBERON:0002367	62.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.81	gold quality
skin of abdomen	UBERON:0001416	60.97	gold quality
thyroid gland	UBERON:0002046	60.72	gold quality
anterior cingulate cortex	UBERON:0009835	60.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-519e-5p regulates malignant phenotype of breast cancer cells through binding to CTPS1. (PMID:39197579)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.