MIR520A

Summary

MIR520A (microRNA 520a, HGNC:32099) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574467 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32099
Approved symbol	MIR520A
Name	microRNA 520a
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520a
Ensembl gene	ENSG00000207594
Ensembl biotype	miRNA
OMIM	620588
Entrez	574467
RNAcentral	URS000075D78D — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384862

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384862 — 1 exons

Exon	Start	End
ENSE00001809174	53690881	53690965

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 78.38.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.38	gold quality
right lobe of liver	UBERON:0001114	72.58	gold quality
skin of abdomen	UBERON:0001416	71.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.55	gold quality
blood	UBERON:0000178	68.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.76	gold quality
ascending aorta	UBERON:0001496	68.38	gold quality
body of stomach	UBERON:0001161	65.47	gold quality
tibial artery	UBERON:0007610	64.87	gold quality
transverse colon	UBERON:0001157	64.67	gold quality
body of uterus	UBERON:0009853	63.91	gold quality
ectocervix	UBERON:0012249	63.61	gold quality
vagina	UBERON:0000996	63.43	gold quality
urinary bladder	UBERON:0001255	62.95	gold quality
skin of leg	UBERON:0001511	62.72	gold quality
thoracic mammary gland	UBERON:0005200	62.55	gold quality
Ammon’s horn	UBERON:0001954	62.27	gold quality
tibial nerve	UBERON:0001323	60.41	gold quality
spleen	UBERON:0002106	57.94	gold quality
right frontal lobe	UBERON:0002810	54.52	gold quality
right testis	UBERON:0004534	48.22	gold quality
left testis	UBERON:0004533	46.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• Data indicate that STAT3 transcription factoris a potential target of miR-520a-5p. (PMID:24870597)
• For selected miRNAs, namely miR-149, miR-148b, miR-326, and miR-520a-3p, we demonstrate the simultaneous downregulation of the ErbB3 receptor and multiple downstream signaling molecules. (PMID:25630670)
• miR218 and miR520a are crucial in the development of hepatocellular carcinoma via the inhibition of cell proliferation and cycle progression by downregulating E2F2. (PMID:25816091)
• These findings provide evidence that a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3’-UTR may play a role in the etiology of colorectal cancer (PMID:25834816)
• microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non small cell lung cancer cells and restoration of microRNA-520a-3p might be a therapeutic strategy to reverse gefitinib resistance. (PMID:27748920)
• This study highlights a tumor suppressor role for miR-520a-3p in colorectal cancer via the regulation of EGFR expression. (PMID:28738328)
• results suggested that miR-520a-3p could suppress the non-small cell lung cancer proliferation, migration and invasion through PI3K/AKT/mTOR signaling pathway. (PMID:29762835)
• miRNA-520a reduced hepatitis b virus transcription and replication by reducing AKT levels. (PMID:30191752)
• High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis. (PMID:32499446)
• [miR-520a-3p regulates the signaling pathway of cytokine secretion in cervical cancer]. (PMID:33167095)
• MiR-520a-3p inhibits malignant progression of epithelial ovarian cancer by targeting SUV39H1 expression. (PMID:33196969)
• LncRNA XIST acts as a MicroRNA-520 sponge to regulate the Cisplatin resistance in NSCLC cells by mediating BAX through CeRNA network. (PMID:33390811)
• Low-temperature incubation improves both knock-in and knock-down efficiencies by the CRISPR/Cas9 system in Xenopus laevis as revealed by quantitative analysis. (PMID:33515912)
• LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis. (PMID:33753211)
• miR302c3p and miR520a3p suppress the proliferation of cervical carcinoma cells by targeting CXCL8. (PMID:33760117)
• Correlations between vitronectin, miR-520, and miR-34 in patients with stenosis of coronary arteries. (PMID:34652615)
• Long noncoding RNA LINC01748 exerts carcinogenic effects in nonsmall cell lung cancer cell lines by regulating the microRNA520a5p/HMGA1 axis. (PMID:34970695)
• miR-520a-5p regulates Frizzled 9 expression and mediates effects of cigarette smoke and iloprost chemoprevention. (PMID:35149732)
• The microRNA-520a-3p inhibits invasion and metastasis by targeting NF-kappaB signaling pathway in non-small cell lung cancer. (PMID:35247196)
• Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3. (PMID:37625824)
• Tumor suppressor miR-520a inhibits cell growth by negatively regulating PI3K/AKT signaling pathway in acute myeloid leukemia. (PMID:37855060)
• Emerging role of miR-520a in human diseases. (PMID:39154603)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.