MIR520B

Summary

MIR520B (microRNA 520b, HGNC:32105) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574473 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32105
Approved symbol	MIR520B
Name	microRNA 520b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520b
Ensembl gene	ENSG00000207722
Ensembl biotype	miRNA
OMIM	620595
Entrez	574473
RNAcentral	URS0000759D0E — miRNA, 61 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384989

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384989 — 1 exons

Exon	Start	End
ENSE00001499996	53701227	53701287

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 26)

• miR-520b is involved in regulating breast cancer cell migration by targeting HBXIP and IL-8 via a network in which HBXIP promotes migration by stimulating NF-kappaB-mediated IL-8 expression. (PMID:21343296)
• role of miR-520b in the development of hepatocellular carcinoma (PMID:22319632)
• Hepatitis B protein HBx accelerates hepatocarcinogenesis with partner survivin through modulating tumor suppressor miR-520b and oncoprotein HBXIP. (PMID:24886421)
• conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3’UTR of TET1 mRNA (PMID:25824049)
• study highlights the importance of miR-520b in regulating the proliferation and apoptosis of GBM by directly targeting cyclin D1, and miR-520b may represent a potential therapeutic strategy for GBM (PMID:26700671)
• CRCT1 functions as a tumor suppressor gene in ESCC and is regulated by miR-520 g, providing potential therapeutic targets for the treatment of ESCC (PMID:26718216)
• miR-520b/e acts as a tumor suppressor by regulating EGFR in gastric cancer. (PMID:27997901)
• These results indicated that the level of miR-520 might associate with recurrent spontaneous abortion by prompting trophoblast cell apoptosis via PARP1 dependent DNA-damage pathway. (PMID:28042738)
• Downregulation of mir520 is associated with breast cancer. (PMID:28112380)
• our study demonstrated that miR-520b inhibits the malignancy of HNC through regulation of cancer stemness conversion by targeting CD44. (PMID:28515423)
• Bioinformatics predicted the targeting of miR-520b on HDAC4. MiR-520b directly targeted the 3’ untranslated region of HDAC4. MiR-520b decreases HDAC4 expression to control cell proliferation in lung cancer. (PMID:30106218)
• Suppression of Capn4 by miR-520b inhibits the growth and invasion of prostate cancer cells associated with downregulated Wnt/beta-catenin signaling. (PMID:30241050)
• Expression of miR-520b is up-regulated in the non-small cell lung cancer.MiR-520b promotes non-small cell lung cancer tumourigenesis via SPOP-GLI2/3 axis.MiR-520b suppressed SPOP expression through direct targeting its 3’-UTR region. (PMID:30407707)
• High mir520 expression is associated with non-small cell lung cancer metastasis. (PMID:30475986)
• MiR-520b inhibited metastasis and proliferation of non-small cell lung cancer by targeting CHAF1A (PMID:30536318)
• Circular RNA TTBK2 promotes the development of human glioma cells via miR-520b/EZH2 axis. (PMID:31858557)
• MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration (PMID:32214367)
• CircFAT1 Suppresses Colorectal Cancer Development Through Regulating miR-520b/UHRF1 Axis or miR-302c-3p/UHRF1 Axis. (PMID:32379550)
• COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis. (PMID:32389118)
• The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis. (PMID:32497020)
• Expression of activating transcription factor 5 (ATF5) is mediated by microRNA-520b-3p under diverse cellular stress in cancer cells. (PMID:32603335)
• LncRNA SNHG16 drives proliferation, migration, and invasion of lung cancer cell through modulation of miR-520/VEGF axis. (PMID:33015794)
• miR-520b Inhibits IGF-1R to Increase Doxorubicin Sensitivity and Promote Cell Apoptosis in Breast Cancer. (PMID:33116033)
• MiR-520b inhibits endothelial activation by targeting NF-kappaB p65-VCAM1 axis. (PMID:33819467)
• Structural, molecular hybridization and network based identification of miR-373-3p and miR-520e-3p as regulators of NR4A2 human gene involved in neurodegeneration. (PMID:35272569)
• LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling. (PMID:36473367)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.