MIR520C

Summary

MIR520C (microRNA 520c, HGNC:32108) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574476 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32108
Approved symbol	MIR520C
Name	microRNA 520c
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520c
Ensembl gene	ENSG00000207738
Ensembl biotype	miRNA
OMIM	615908
Entrez	574476
RNAcentral	URS00006F562E — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385005

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385005 — 1 exons

Exon	Start	End
ENSE00001500012	53707453	53707539

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 80.01.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.01	gold quality
tibial artery	UBERON:0007610	75.27	gold quality
muscle of leg	UBERON:0001383	74.93	gold quality
gastrocnemius	UBERON:0001388	70.33	gold quality
heart left ventricle	UBERON:0002084	69.93	gold quality
ascending aorta	UBERON:0001496	69.16	gold quality
urinary bladder	UBERON:0001255	67.77	gold quality
esophagus mucosa	UBERON:0002469	66.99	gold quality
body of stomach	UBERON:0001161	65.91	gold quality
body of uterus	UBERON:0009853	65.08	gold quality
vagina	UBERON:0000996	63.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.75	gold quality
transverse colon	UBERON:0001157	63.58	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.97	gold quality
tibial nerve	UBERON:0001323	62.27	gold quality
left testis	UBERON:0004533	49.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-520/373 family has a tumor-suppressive role in ER(-) breast cancer by acting as a link between the NF-kappaB and TGF-beta pathways and may thus contribute to the interplay of tumor progression, metastasis and inflammation. (PMID:22158050)
• Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity. (PMID:24497838)
• we found that miR-373 and -520c down-regulated the activities of MMP2 in various cancer cell lines but simultaneously up-regulated the expression of MMP9 gene only in HT1080 cells (PMID:25545756)
• Data suggest that microRNAs miR-10b, 21, 200c, 373 and 520c may control both metastasis and stemness potential. (PMID:26208390)
• Low miR30d expression is associated with glioma. (PMID:28184932)
• our findings demonstrate that S100A4 is post-transcriptionally regulated by tumor suppressor microRNAs…and particularly miR-520c-3p expression is epigenetically silenced in colorectal cancer (PMID:28423501)
• this study shows that long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge (PMID:28545023)
• aberrant miR-520c-3p expression may lead to reduced IL-8 expression and promote the mesenchymal phenotype in breast cancer cells, thereby increasing invasive growth. (PMID:29048659)
• HOXA-AS2 could negatively regulate the expression of miR-520c-3p in osteosarcoma cells. (PMID:30081707)
• as a potent tumor suppressor, miR-520c-3p shows a significantly lower expression level in lung adenocarcinoma. (PMID:30942957)
• Collectively, miR-520c-3p could potentially inhibit NLRP3 inflammasome activation and inflammatory cascade in preeclampsia (PE) by downregulating NLRP3, highlighting the potential of miR-520c-3p as a therapeutic target for PE treatment. (PMID:31143973)
• LncRNA TPTE2P1 promotes the proliferation of thyroid carcinoma by inhibiting miR-520c-3p. (PMID:31144790)
• MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells. (PMID:32357822)
• MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5. (PMID:32539925)
• MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation. (PMID:33166679)
• MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-kappaB signaling pathways. (PMID:33411212)
• Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. (PMID:35137483)
• Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach. (PMID:35634241)
• Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression. (PMID:36528556)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.