MIR520E

Summary

MIR520E (microRNA 520e, HGNC:32093) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574461 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32093
Approved symbol	MIR520E
Name	microRNA 520e
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520e
Ensembl gene	ENSG00000207599
Ensembl biotype	miRNA
OMIM	620573
Entrez	574461
RNAcentral	URS00006EE977 — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384867

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384867 — 1 exons

Exon	Start	End
ENSE00001808569	53675711	53675797

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 75.06.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	75.06	gold quality
monocyte	CL:0000576	73.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.70	gold quality
ascending aorta	UBERON:0001496	67.80	gold quality
esophagus mucosa	UBERON:0002469	65.67	gold quality
transverse colon	UBERON:0001157	64.39	gold quality
right ovary	UBERON:0002118	63.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.17	gold quality
endocervix	UBERON:0000458	61.97	gold quality
tibial nerve	UBERON:0001323	60.68	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The results suggested that miR-520e suppresses the growth of hepatoma cells by targeting NF-kappa B-inducing kinase. Intratumoral injection of miR-520e was able to directly repress the growth of hepatoma cells in nude mice. (PMID:22105365)
• miR-141/YWHAG and miR-520e/RAB11A are two potential miRNA/protein target pairs associated with severe obesity. (PMID:22537031)
• miR-520b/e acts as a tumor suppressor by regulating EGFR in gastric cancer. (PMID:27997901)
• Data suggest that microRNA miR-520e directly targets to the 3’-untranslated region (3’-UTR) of zinc finger and BTB domain containing 7A protein (Zbtb7a). (PMID:28242196)
• MiR-520e is upregulated in hepatitis B virus (HBV)-positive HCC tissues and cells. MiR-520e is decreased in Huh7-X and HepG2-X cells in which hepatitis B virus X protein (HBx) is stably expressed. MiR-520e mimic is reduced in association with increases in HBV DNA content, HBsAg and HBeAg levels, cell proliferation and is enhanced in the expressions of EphA2, p-p38MAPK/p38MAPK, and cell apoptosis. (PMID:30521133)
• miR-520e restricts glioma cell proliferation and invasion. miR-520e targets FGF19 3’-UTR to repress its expression. (PMID:30826062)
• LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling. (PMID:36473367)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.