MIR520F

Summary

MIR520F (microRNA 520f, HGNC:32096) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574464 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32096
Approved symbol	MIR520F
Name	microRNA 520f
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520f
Ensembl gene	ENSG00000283540
Ensembl biotype	miRNA
OMIM	620585
Entrez	574464
RNAcentral	URS000072A937 — miRNA, 87 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384824

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384824 — 1 exons

Exon	Start	End
ENSE00001809274	53682159	53682245

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 69.78.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	69.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.98	gold quality
nucleus accumbens	UBERON:0001882	62.79	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
left testis	UBERON:0004533	46.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f. (PMID:25137037)
• study revealed that the expression levels of miR-520f were significantly down-regulated in gastric carcinoma cells and clinical gastric carcinoma samples; study also demonstrated that introduction of miR-520f inhibited the growth of gastric carcinoma cells in vitro (PMID:27565325)
• Study found that miR-520f was remarkably down-regulated in human hepatocellular carcinoma (HCC) samples and cell lines and that deregulated miR-520f was strongly associated with larger tumor size, advanced TNM stage, and metastasis in HCC patients. These data indicated that miR-520f acted as tumor suppressor in HCC proliferation and invasion by targeting TM4SF1. (PMID:29505836)
• Data show that mir-520f rs75598818 GA genotype was significantly associated with breast cancer (BC). (PMID:30555079)
• The expression of microRNA 520f (miR-520f) is significantly down-regulated in non-small cell lung cancer (NSCLC) and acts as a tumor inhibitor. Circular RNA, hsa_circ_0043278 promotes NSCLC cell proliferation, invasion, and migration by sponging miR-520f, which targets proto-oncogene proteinsROCK1, CDKN1B, and AKT3 in NSCLC cells. (PMID:30873868)
• Serum miR-520f was down-regulated in lung cancer patients compared with healthy group. Moreover, the expression of miR-520f was significantly associated with advanced TNM stage and metastasis. The area under the curve (AUC) value of ROC curve was 0.888, suggesting that miR-520f could be a diagnostic biomarker for lung cancer. The cut-off value of serum miR-520f for lung cancer diagnosis was 1.815. (PMID:31348274)
• MicroRNA-520f-3p inhibits proliferation of gastric cancer cells via targeting SOX9 and thereby inactivating Wnt signaling. (PMID:32277152)
• Knockdown of lncRNA SNHG20 Suppressed the Proliferation of Cholangiocarcinoma by Sponging miR-520f-3p. (PMID:32907346)
• Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis. (PMID:39097891)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.