MIR520G

Summary

MIR520G (microRNA 520g, HGNC:32116) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574484 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32116
Approved symbol	MIR520G
Name	microRNA 520g
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520g
Ensembl gene	ENSG00000207799
Ensembl biotype	miRNA
OMIM	616272
Entrez	574484
RNAcentral	URS000068CB78 — miRNA, 90 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385064

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385064 — 1 exons

Exon	Start	End
ENSE00001500070	53722166	53722255

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 79.43.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	79.43	gold quality
stomach	UBERON:0000945	78.18	gold quality
skin of abdomen	UBERON:0001416	75.95	gold quality
hypothalamus	UBERON:0001898	75.44	gold quality
blood	UBERON:0000178	71.58	gold quality
vagina	UBERON:0000996	69.52	gold quality
ascending aorta	UBERON:0001496	69.43	gold quality
body of pancreas	UBERON:0001150	68.49	gold quality
esophagus mucosa	UBERON:0002469	68.46	gold quality
transverse colon	UBERON:0001157	66.76	gold quality
right adrenal gland	UBERON:0001233	66.30	gold quality
tibial artery	UBERON:0007610	65.84	gold quality
left ovary	UBERON:0002119	64.69	gold quality
skin of leg	UBERON:0001511	64.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.52	gold quality
omental fat pad	UBERON:0010414	63.18	gold quality
minor salivary gland	UBERON:0001830	61.97	gold quality
spleen	UBERON:0002106	58.20	gold quality
left testis	UBERON:0004533	45.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus (PMID:19962671)
• A major implication of our studies is that inhibition of miR-520g or restoration of p21 expression may have considerable therapeutic potential to overcome drug resistance in colorectal cancer patients, especially in those with mutant p53. (PMID:25616665)
• Highly expressed mir-520g is associated with lymph node metastasis and low differentiation of breast cancer. (PMID:26957267)
• This study suggests that miR-520g contributes to tumor progression and drug resistance by post-transcriptionally downregulating DAPK2 in patients with epithelial ovarian cancer (PMID:27049921)
• Elevated maternal serum level of miR-520g level in first trimester was detected in patients with severe preeclampsia. (PMID:28292471)
• Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis. (PMID:34060415)
• Long non-coding RNA IGF2-AS promotes trophoblast cell proliferation, migration, and invasion by regulating miR-520g/N-cadherin axis. (PMID:34109707)
• Circ_0000317/microRNA-520g/HOXD10 axis affects the biological characteristics of colorectal cancer. (PMID:34292663)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.